Evidence-Based Medicine
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2023; 15(7): 1295-1310
Published online Jul 15, 2023. doi: 10.4251/wjgo.v15.i7.1295
Comprehensive bioinformatic analysis of mind bomb 1 gene in stomach adenocarcinoma
Di Wang, Qi-Hong Wang, Ting Luo, Wen Jia, Jing Wang
Di Wang, Qi-Hong Wang, Ting Luo, Wen Jia, Jing Wang, Department of Digestive Endoscopy, The General Hospital of Northern Theater Command, Shenyang 110840, Liaoning Province, China
Di Wang, Qi-Hong Wang, Ting Luo, Postgraduate College, China Medical University, Shenyang 110840, Liaoning Province, China
Author contributions: Wang J contributed to conceptualization; Wang D wrote the paper; Wang QH, Luo T, and Jia W collected and analyzed data.
Supported by the Science and Technology Program of Liaoning Province, No. 2021-MS-040.
Conflict-of-interest statement: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
PRISMA 2009 Checklist statement: We have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing Wang, MS, Deputy Director, Department of Digestive Endoscopy, The General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenhe District, Shenyang 110840, Liaoning Province, China. 13309882063@163.com
Received: February 27, 2023
Peer-review started: February 27, 2023
First decision: March 14, 2023
Revised: March 27, 2023
Accepted: May 8, 2023
Article in press: May 8, 2023
Published online: July 15, 2023
Processing time: 135 Days and 3.3 Hours
Core Tip

Core Tip: NOTCH signaling pathway is involved in the occurrence and development of many tumors. Mind bomb 1 (MIB1) is one of many E3 ubiquitin ligases in ubiquitin proteasome system, which plays a key role in NOTCH signaling pathway. Several studies showed that MIB1 participated in the proliferation and metastasis of certain tumor cells, but its role in gastric cancer (GC) remained still unclear. The purpose of our study was to elucidate the relationship between MIB1 gene and GC and provide a new idea for the treatment of GC.