Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2023; 15(7): 1283-1294
Published online Jul 15, 2023. doi: 10.4251/wjgo.v15.i7.1283
Efficacy of continuous gastric artery infusion chemotherapy in relieving digestive obstruction in advanced gastric cancer
Rui Tang, Guo-Feng Chen, Kai Jin, Guang-Qiang Zhang, Jian-Jun Wu, Shu-Gao Han, Bin Li, Ming Chao
Rui Tang, Kai Jin, Guang-Qiang Zhang, Jian-Jun Wu, Shu-Gao Han, Bin Li, Ming Chao, Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China
Guo-Feng Chen, Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China
Author contributions: Tang R reviewed the literature and contributed to article drafting and statistical analysis; Li B was responsible for data acquisition and revision of the manuscript; Chao M was in charge of this project and responsible for the final revision of the manuscript; Chen GF was a surgeon from Department of Gastrointestinal Surgery, and was responsible for the evaluation of surgical indications of all patients; Jin K, and Zhang GQ were interventional physicians from the Department of Radiology, and participated in the diagnosis and treatment of patients; Wu JJ, and Han SG were experienced radiologists responsible for assessment of radiology response; all authors gave final approval for the version to be submitted.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of The Second Affiliated Hospital of Zhejiang University School of Medicine (Approval No. I2020001737).
Informed consent statement: All study participants or their legal guardian gave signed informed consent.
Conflict-of-interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Data sharing statement: Dataset available from the corresponding author at chaoming@zju.edu.cn. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ming Chao, MD, Professor, Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou 310000, Zhejiang Province, China. chaoming@zju.edu.cn
Received: March 27, 2023
Peer-review started: March 27, 2023
First decision: May 4, 2023
Revised: May 17, 2023
Accepted: June 8, 2023
Article in press: June 8, 2023
Published online: July 15, 2023
Processing time: 107 Days and 3.3 Hours
Core Tip

Core Tip: This was a retrospective study to evaluate the effectiveness of continuous gastric artery infusion chemotherapy (cGAIC) in relieving digestive obstruction in advanced gastric cancer patients. The overall response rate was 89.7% after cGAIC. A total of 75.9% of patients experienced relief of digestive obstruction after the first two cycles, and 44.8% of initially unresectable patients were then considered radically resectable. The median overall survival was 16 mo. C-arm computed tomography angiography helped to precisely confirm the tumor-feeding artery. Our new treatment can not only help relieve patients with digestive obstruction but also provide a good prognosis in treating tumors.