Basic Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jun 15, 2023; 15(6): 988-1004
Published online Jun 15, 2023. doi: 10.4251/wjgo.v15.i6.988
Transcription factor glucocorticoid modulatory element-binding protein 1 promotes hepatocellular carcinoma progression by activating Yes-associate protein 1
Cheng Chen, Hai-Guan Lin, Zheng Yao, Yi-Ling Jiang, Hong-Jin Yu, Jing Fang, Wei-Na Li
Cheng Chen, Yi-Ling Jiang, Hong-Jin Yu, Jing Fang, Wei-Na Li, Department of Medical Oncology, Zhejiang Xiaoshan Hospital, Hangzhou 311202, Zhejiang Province, China
Hai-Guan Lin, Department of General Surgery, People’s Liberation Army Strategic Support Force Characteristic Medical Center, Beijing 100101, China
Zheng Yao, Department of Radiation Oncology, Cancer Hospital of The University of Chinese Academy of Sciences, Hangzhou 310022, Zhejiang Province, China
Author contributions: Chen C and Lin HG contributed equally to this work; Chen C, Lin HG and Yao Z designed the research; Lin HG, Yao Z, Jiang YL and Yu HJ contributed to methodological establishment and completion of experiments; Lin HG, Yao Z, Jiang YL, Yu HJ, Fang J and Li WN analyzed and interpreted the data; Chen C and Lin HG drafted the manuscript; Chen C and Fang J and Li WN critically revised the manuscript for important intellectual content.
Institutional review board statement: The study was reviewed and approved by Ethics Committee of Zhejiang Xiaoshan Hopital.
Institutional animal care and use committee statement: The experimental protocol was approved by the Animal Care and Use Committee of Zhejiang Xiaoshan Hopital.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Cheng Chen, MM, Attending Doctor, Department of Medical Oncology, Zhejiang Xiaoshan Hospital, No. 728 Yucai North Road, Xiaoshan District, Hangzhou 311202, Zhejiang Province, China. chencheng858@126.com
Received: January 17, 2023
Peer-review started: January 17, 2023
First decision: February 28, 2023
Revised: March 18, 2023
Accepted: April 12, 2023
Article in press: April 12, 2023
Published online: June 15, 2023
Processing time: 148 Days and 18.2 Hours
Core Tip

Core Tip: Glucocorticoid modulatory element-binding protein 1 (GMEB1) was highly expressed in hepatocellular carcinoma (HCC) tissues. Functionally, GMEB1 modulates the malignant biological behaviors of HCC cells. Mechanistically, GMEB1 promotes the expression of Yes-associate protein 1 at transcriptional level. In short, the present study suggested that for HCC, GMEB1 might be a diagnostic biomarker and treatment target.