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World J Gastrointest Oncol. Jun 15, 2023; 15(6): 943-958
Published online Jun 15, 2023. doi: 10.4251/wjgo.v15.i6.943
Vitamin E in the management of pancreatic cancer: A scoping review
Sophia Ogechi Ekeuku, Effiong Paul Etim, Kok-Lun Pang, Kok-Yong Chin, Chun-Wai Mai
Sophia Ogechi Ekeuku, Kok-Yong Chin, Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia
Effiong Paul Etim, Faculty of Applied Sciences, UCSI University, Kuala Lumpur 56000, Malaysia
Kok-Lun Pang, Newcastle University Medicine Malaysia, Iskandar Puteri 79200, Johor, Malaysia
Kok-Yong Chin, Chun-Wai Mai, State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Chun-Wai Mai, Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur 56000, Malaysia
Author contributions: Ekeuku SO, Etim EP, Pang KL, Chin KY, Mai CW were involved in the data collection and validation; Ekeuku SO, Etim EP provided the first draft of the manuscript; Ekeuku SO, Etim BP, Mai CW prepared the figures and tables; Ekeuku SO, Etim EP, Pang KL, Chin KY, Mai CW wrote and finalized the manuscript; Chin KY and Mai CW designed the outline and coordinated the writing of the paper.
Supported by Universiti Kebangsaan Malaysia Through Research University Grant, No. GUP-2020-021; and Shanghai Municipal Science and Technology Commission, No. 20WZ2504600.
Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chun-Wai Mai, BPharm, PhD, Associate Professor, Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, UCSI University, No. 1, Jalan Menara Gading, UCSI Heights (Taman Connaught), Cheras, Kuala Lumpur 56000, Malaysia. mai.chunwai@gmail.com
Received: November 8, 2022
Peer-review started: November 8, 2022
First decision: January 3, 2023
Revised: February 3, 2023
Accepted: April 7, 2023
Article in press: April 7, 2023
Published online: June 15, 2023
Processing time: 218 Days and 17.2 Hours
Core Tip

Core Tip: Vitamin E is a natural bioactive agent found in a variety of foods. Our scoping review found that it inhibits pancreatic tumor progression, and modulates key pathways in carcinogenesis. Vitamin E might support the current pharmacological approach for treating pancreatic cancer. However, more studies are needed to investigate its safety and efficacy.