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World J Gastrointest Oncol. Feb 15, 2023; 15(2): 276-285
Published online Feb 15, 2023. doi: 10.4251/wjgo.v15.i2.276
Evaluation of polygenic risk score for risk prediction of gastric cancer
Xiao-Yu Wang, Li-Li Wang, Lin Xu, Shu-Zhen Liang, Meng-Chao Yu, Qiu-Yue Zhang, Quan-Jiang Dong
Xiao-Yu Wang, Li-Li Wang, Lin Xu, Shu-Zhen Liang, Meng-Chao Yu, Quan-Jiang Dong, Central Laboratories and Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, Shandong Province, China
Qiu-Yue Zhang, Department of Clinical Laboratory, the Eighth Medical Center of the General Hospital of the People’s Liberation Army, Beijing 100000, China
Author contributions: Wang XY and Liang SZ collected sequencing data; Wang LL and Xu L analyzed the data; Wang XY, Yu MC, and Zhang QY wrote the manuscript; Dong QJ designed the research and supervised the manuscript; all authors reviewed the manuscript and approved the final version of the manuscript.
Supported by the National Natural Science Foundation of China, No. 31870777.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Quan-Jiang Dong, MD, PhD, Chief Doctor, Professor, Central Laboratories and Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao University, No. 5 Donghai Middle Road, Qingdao 266071, Shandong Province, China. allyking114@126.com
Received: November 18, 2022
Peer-review started: November 18, 2022
First decision: January 3, 2023
Revised: January 11, 2023
Accepted: February 2, 2023
Article in press: February 2, 2023
Published online: February 15, 2023
Processing time: 88 Days and 22.4 Hours
Core Tip

Core Tip: A systematic review was conducted to evaluate current polygenic risk score (PRS) models in gastric cancer risk prediction. Our study showed that PRS models had the potential to predict the risk of gastric cancer with a moderate accuracy. The prediction models’ performance could be improved after incorporating epidemiological factors or Helicobacter pylori (H. pylori) status. The potential of H. pylori genomic variations and members of the gastric microbiome were discussed as candidates for gastric cancer prediction models.