Copyright
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Feb 15, 2023; 15(2): 268-275
Published online Feb 15, 2023. doi: 10.4251/wjgo.v15.i2.268
Published online Feb 15, 2023. doi: 10.4251/wjgo.v15.i2.268
Serum biomarkers for the differentiation of autoimmune pancreatitis from pancreatic ductal adenocarcinoma
Octavio Caba, Cristina Jiménez-Luna, Institute of Biopathology and Regenerative Medicine (IBIMER), University of Granada, Granada 18016, Spain
Octavio Caba, Cristina Jiménez-Luna, Biosanitary Institute of Granada (ibs.GRANADA), 18014 Granada, Spain
Carmelo Diéguez-Castillo, Department of Gastroenterology, San Cecilio University Hospital, Granada 18016, Spain
Joaquina Martínez-Galán, Department of Medical Oncology, Virgen de las Nieves University Hospital, Granada 18014, Spain. Biosanitary Institute of Granada (ibs.GRANADA), 18014 Granada, Spain
Irene González-Cebrián, Department of Digestive Cancer, San Cecilio University Hospital, Granada 18016, Spain
Author contributions: Caba O designed the overall concept and outline of the manuscript; Diéguez-Castillo C, Martínez-Galán J, and González-Cebrián I contributed to the discussion, and carried out the design of the manuscript; Diéguez-Castillo C and Jiménez-Luna C contributed to the writing and editing of the manuscript and review of the literature.
Supported by Fondos Feder , No. A-CTS-436-UGR20.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Carmelo Diéguez-Castillo, MD, PhD, Research Scientist, Department of Gastroenterology, San Cecilio University Hospital, Avenida del Conocimiento, s/n, Granada 18016, Spain. carmelo89dc@gmail.com
Received: September 20, 2022
Peer-review started: September 20, 2022
First decision: November 15, 2022
Revised: November 29, 2022
Accepted: January 17, 2023
Article in press: January 17, 2023
Published online: February 15, 2023
Processing time: 147 Days and 2.8 Hours
Peer-review started: September 20, 2022
First decision: November 15, 2022
Revised: November 29, 2022
Accepted: January 17, 2023
Article in press: January 17, 2023
Published online: February 15, 2023
Processing time: 147 Days and 2.8 Hours
Core Tip
Core Tip: The imaging and clinical features of autoimmune pancreatitis commonly overlap with those of pancreatic ductal adenocarcinoma. This study reviews the most recent and relevant serum biomarkers proposed to differentiate between these diseases of the pancreas, including serum immunoglobulins, autoantibodies, chemokines, and cytokines, evaluating their usefulness for this purpose. One of the key conclusions is that a panel of various serum biomarkers appears to be necessary for an accurate differentiation between these diseases, either alone or in combination with clinical data and/or radiological images. Importantly, further research is warranted to assess the usefulness of these promising serum biomarkers in clinical practice