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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Feb 15, 2023; 15(2): 251-267
Published online Feb 15, 2023. doi: 10.4251/wjgo.v15.i2.251
Published online Feb 15, 2023. doi: 10.4251/wjgo.v15.i2.251
Is the combination of immunotherapy with conventional chemotherapy the key to increase the efficacy of colorectal cancer treatment?
Jonadab E Olguin, Luis I Terrazas, Laboratorio Nacional en Salud, Diagnóstico Molecular y Efecto Ambiental en Enfermedades Crónico-degenerativas, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla 54090, Estado de Mexico, Mexico
Monica G Mendoza-Rodriguez, C Angel Sanchez-Barrera, Luis I Terrazas, Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla 54090, Estado de Mexico, Mexico
Author contributions: Olguin JE and Mendoza-Rodriguez MG contributed equally to this work; Olguin JE, Mendoza-Rodriguez MG, and Terrazas LI contributed to conception and design; Olguin JE and Terrazas LI contributed to the search for information related to the immune response; Mendoza-Rodriguez MG and Sanchez-Barrera CA contributed to the search for information related to chemotherapy; Olguin JE and Mendoza-Rodriguez MG contributed to figure development; Olguin JE, Mendoza-Rodriguez MG, Sanchez-Barrera CA, and Terrazas LI contributed to paper writing; Olguin JE, Mendoza-Rodriguez MG, and Terrazas LI contributed to funding resources.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Luis I Terrazas, PhD, Chairman, Senior Scientist, Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Avenida de los Barrios # 1, Tlalnepantla 54090, Estado de México, Mexico.
Received: September 24, 2022
Peer-review started: September 24, 2022
First decision: October 20, 2022
Revised: November 3, 2022
Accepted: January 10, 2023
Article in press: January 10, 2023
Published online: February 15, 2023
Processing time: 143 Days and 23 Hours
Peer-review started: September 24, 2022
First decision: October 20, 2022
Revised: November 3, 2022
Accepted: January 10, 2023
Article in press: January 10, 2023
Published online: February 15, 2023
Processing time: 143 Days and 23 Hours
Core Tip
Core Tip: This review focused on the drugs that may modulate the immune response and show specific efficacy in the treatment of colorectal cancer. We then presented the evidence that immunosuppression or promotion of the immune response is the answer to generating effective treatments with combined chemotherapeutic drugs.