Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Nov 15, 2023; 15(11): 2033-2040
Published online Nov 15, 2023. doi: 10.4251/wjgo.v15.i11.2033
Response of cholangiocarcinoma with epigastric metastasis to lenvatinib plus sintilimab: A case report and review of literature
Wen-Hui Luo, Shao-Jun Li, Xue-Feng Wang
Wen-Hui Luo, Shao-Jun Li, Xue-Feng Wang, The Second Department of Hepatobiliary Surgery, Yantai Yuhuangding Hospital, Yantai 264000, Shandong Province, China
Co-first authors: Wen-Hui Luo and Shao-Jun Li.
Author contributions: Li SJ provided insights into the direction of this study and assisted in the writing. For example, Li SJ and two other authors proposed at the beginning of the article that liver is an immunological preferential organ with strong immune tolerance, which may affect the development of metastatic tumors. During the writing process, Li SJ collected images, such as Figure 1 for magnetic resonance imaging images of patients before surgery, Figure 2 for baseline magnetic resonance imaging images before targeted immunotherapy, and Figure 4 for magnetic resonance imaging images of different tumor sites after treatment, to find out typical and clear pictures, and labeled typical lesions in the figures at each stage. Additionally, he provided necessary help for literature search, such as finding new articles on targeted immunization of cholangiocarcinoma. After the completion of the writting, the co-first authors reviewed the paper and corrected language logic problems. When looking for a journal to submit our study, we have sought for the opinions of Li SJ and we all think it is appropriate to submit our article to the World Journal of Gastrointestinal Oncology.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xue-Feng Wang, MD, Associate Chief Physician, Doctor, The Second Department of Hepatobiliary Surgery, Yantai Yuhuangding Hospital, No. 20 Yuhuangding East Road, Zhifu District, Yantai 264000, Shandong Province, China. seasonslo@126.com
Received: July 6, 2023
Peer-review started: July 6, 2023
First decision: September 5, 2023
Revised: September 15, 2023
Accepted: September 28, 2023
Article in press: September 28, 2023
Published online: November 15, 2023
Processing time: 132 Days and 6.6 Hours
Core Tip

Core Tip: Cholangiocarcinoma (CCA) is a highly lethal hepatobiliary neoplasm. This report presents a case with advanced CCA who received immunotherapy, revealing differences in treatment responses between intrahepatic vs. extrahepatic epigastric metastatic sites. This hitherto unreported phenomenon prompted us to investigate the differential outcomes of these metastatic patterns following treatment with lenvatinib combined with sintilimab, culminating in a summary report elucidating potential underlying mechanisms.