Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2023; 15(10): 1807-1822
Published online Oct 15, 2023. doi: 10.4251/wjgo.v15.i10.1807
Synchronous occurrence of gastric cancer and gastrointestinal stromal tumor: A case report and review of the literature
Jie Liu, Bin-Jie Huang, Fei-Fei Ding, Fu-Tian Tang, Yu-Min Li
Jie Liu, Bin-Jie Huang, Fei-Fei Ding, Fu-Tian Tang, Yu-Min Li, Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China
Jie Liu, Bin-Jie Huang, Fei-Fei Ding, Fu-Tian Tang, Yu-Min Li, Key Laboratory of the Digestive System Tumors of Gansu Province, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China
Author contributions: Liu J performed data collection, statistical analysis, literature collection, and manuscript writing; Huang BJ, Tang FT, and Ding FF participated in the investigation and revision; Li YM designed, supervised, and guided this study; and all authors contributed to the article and approved the submitted version.
Supported by the Fundamental Research Funds for the Central Universities, No. lzujbky-2022-sp08.
Informed consent statement: Informed written or verbal consent were obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu-Min Li, MD, PhD, Chief Physician, Professor, Surgeon, Surgical Oncologist, Department of General Surgery, Lanzhou University Second Hospital, No. 80 Cuiyingmen, Lanzhou 730030, Gansu Province, China. liym@lzu.edu.cn
Received: May 31, 2023
Peer-review started: May 31, 2023
First decision: July 31, 2023
Revised: August 20, 2023
Accepted: September 14, 2023
Article in press: September 14, 2023
Published online: October 15, 2023
Processing time: 131 Days and 17.8 Hours
Core Tip

Core Tip: We conclude that there are specific clinicopathological features in gastric cancer (GC) and gastrointestinal stromal tumor (GIST), as is often seen in older men; GC is usually a poorly differentiated enterotype early adenocarcinoma located in the lower third of the stomach. GIST is usually small in diameter, low or very low risk, and located in the body of the stomach. We hypothesized that GC and GIST might be affected by the same unknown carcinogen, leading to the simultaneous proliferation of epithelial and mesenchymal cells. GC and GIST may inhibit each other in the occurrence and development of the disease.