Meta-Analysis
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jan 15, 2023; 15(1): 171-185
Published online Jan 15, 2023. doi: 10.4251/wjgo.v15.i1.171
Rs3746444 T>C locus in miR-499 increases the susceptibility to hepatocellular carcinoma: A meta-analysis 14812 subjects
Jia-Kai Jiang, Han-Shen Chen, Wei-Feng Tang, Yu Chen, Jing Lin
Jia-Kai Jiang, Department of General Surgery, Changzhou No. 3 People’s Hospital, Changzhou 213000, Jiangsu Province, China
Han-Shen Chen, Department of Anesthesiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350000, Fujian Province, China
Wei-Feng Tang, Department of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210000, Jiangsu Province, China
Yu Chen, Jing Lin, Department of Medical Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350000, Fujian Province, China
Yu Chen, Jing Lin, Cancer Bio-Immunotherapy Center, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350000, Fujian Province, China
Yu Chen, College of Chemistry, Fuzhou University, Fuzhou 350000, Fujian Province, China
Author contributions: Jiang JK and Chen HS contributed to this manuscript equally. Jiang JK, Lin J, Chen Y contributed to the conception of the study; Chen HS and Tang WF contributed significantly to the analysis and manuscript preparation; Jiang JK, Chen Y performed the data analyses and wrote the manuscript; HS Chen and Lin J helped perform the analysis with constructive discussions.
Supported by Fujian Provincial Clinical Research Center for Cancer Radiotherapy and Immunotherapy, No. 2020Y2012; the Startup Fund for Scientific Research, Fujian Medical University, No. 2019QH1071; the Science and Technology Supporting Project of Changzhou City, No. CE20205034; Joint Funds for the Innovation of Science and Technology, Fujian Province, No. 2021Y9227; and the National Natural Science Foundation of China, No. U1705282.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing Lin, MA, Doctor, Department of Medical Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, No. 420 Fuma Road, Jin’an District, Fuzhou 350000, Fujian Province, China. 423559148@qq.com
Received: October 1, 2022
Peer-review started: October 1, 2022
First decision: October 20, 2022
Revised: October 26, 2022
Accepted: November 28, 2022
Article in press: November 28, 2022
Published online: January 15, 2023
Processing time: 100 Days and 18.6 Hours
Core Tip

Core Tip: Many investigations have suggested that the rs3746444 T>C locus in the microRNA (miR)-499 gene may contribute to the occurrence of cancer. However, reports on the association between rs3746444 and hepatocellular carcinoma (HCC) are conflicting. This meta-analysis highlights that rs3746444 in the miR-499 gene is involved in the occurrence of HCC, especially in Asian individuals.