Basic Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Aug 15, 2022; 14(8): 1499-1509
Published online Aug 15, 2022. doi: 10.4251/wjgo.v14.i8.1499
Safety and feasibility of irreversible electroporation for the pancreatic head in a porcine model
Li Yan, Bin Liang, Jian Feng, Hang-Yu Zhang, Hao-Sheng Chang, Bing Liu, Yong-Liang Chen
Li Yan, Bin Liang, Hang-Yu Zhang, Hao-Sheng Chang, Bing Liu, Yong-Liang Chen, Faculty of Hepato-Pancreato-Biliary Surgery, Institute of Hepatobiliary Surgery of Chinese PLA, Key Laboratory of Digital Hepetobiliary Surgery, The First Medical Centre, Chinese PLA General Hospital, Beijing 100853, China
Jian Feng, Department of Hepatopancreatobiliary Surgery, Peking University Shougang Hospital, Beijing 100144, China
Author contributions: Yan L and Chen YL designed and coordinated the study; Yan L, Liang B, and Feng J performed the experiments, and acquired and analyzed the data; Zhang HY, Chang HS, and Liu B interpreted the data; Yan L and Feng J wrote the manuscript; Liang B and Feng J should be regarded as co-first authors; all authors approved the final version of the article.
Institutional review board statement: The manuscript does not include human experiments.
Institutional animal care and use committee statement: The operational procedures for the animal experiments were approved by the Institutional Animal Care and Use Committee (IACUC) of PLA General Hospital (No. 2016-D12-02).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong-Liang Chen, MD, PhD, Director, Doctor, Faculty of Hepato-Pancreato-Biliary Surgery, Institute of Hepatobiliary Surgery of Chinese PLA, Key Laboratory of Digital Hepetobiliary Surgery, The First Medical Centre, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. chenyongl301@163.com
Received: April 6, 2022
Peer-review started: April 6, 2022
First decision: May 10, 2022
Revised: May 12, 2022
Accepted: July 11, 2022
Article in press: July 11, 2022
Published online: August 15, 2022
Processing time: 126 Days and 3.7 Hours
Core Tip

Core Tip: This is a basic experimental research paper on irreversible electroporation (IRE) in the pancreatic head region. To examine the feasibility and safety of this technique in Landrace pigs, we designed a series of research experiments. We found that IRE ablation to the pancreatic head may be safe and feasible without long-term damage to the surrounding vital structures. However, risks of stress injuries in acute phase should be taken into consideration to prevent severe perioperative complications.