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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Aug 15, 2022; 14(8): 1429-1445
Published online Aug 15, 2022. doi: 10.4251/wjgo.v14.i8.1429
Published online Aug 15, 2022. doi: 10.4251/wjgo.v14.i8.1429
Lymph node regression grading of locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy
Lei He, Juan Xiao, School of Medicine, University of Electronic Science and Technology of China, Chengdu 611731, Sichuan Province, China
Ping Zheng, Department of Pathology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, Sichuan Province, China
Lei Zhong, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu 610072, Sichuan Province, China
Qian Peng, Radiation Therapy Center, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, Sichuan Province, China
Author contributions: He L performed the literature review and wrote the paper; He L, Xiao J, Zhong L, and Zheng P collected the pathology data; all authors have read and approved the final manuscript.
Supported by Chengdu Science and Technology Project , No. 2021-YF05-01484-SN ; Excellent Youth Foundation Project of Sichuan Cancer Hospital , No. YB2021037 ; and Foundation Project of Health Commission of Sichuan Province , No. 20PJ112 .
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qian Peng, MD, PhD, Associate Chief Physician, Doctor, Radiation Therapy Center, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, No. 55 Section 4, Renmin South Road, Chengdu 610041, Sichuan Province, China. pengqian0522@163.com
Received: March 8, 2022
Peer-review started: March 8, 2022
First decision: April 17, 2022
Revised: April 30, 2022
Accepted: July 6, 2022
Article in press: July 6, 2022
Published online: August 15, 2022
Peer-review started: March 8, 2022
First decision: April 17, 2022
Revised: April 30, 2022
Accepted: July 6, 2022
Article in press: July 6, 2022
Published online: August 15, 2022
Core Tip
Core Tip: Studies on lymph node regression grading after neoadjuvant chemoradiotherapy (nCRT) for rectal cancer are limited but serve clinicians for assessing the lymph node response to treatment based on the efficacy of the primary tumor after preoperative nCRT, providing guidance in formulating more accurate surgical or therapeutic strategies for the next stage of patient management and in determining patient prognosis. We discuss its histopathology, prognosis, correlation with tumor regression grading, and clinical applications and prospects.