Mao D, Flynn DE, Yerkovich S, Tran K, Gurunathan U, Chandrasegaram MD. Effect of obesity on post-operative outcomes following colorectal cancer surgery. World J Gastrointest Oncol 2022; 14(7): 1324-1336 [PMID: 36051092 DOI: 10.4251/wjgo.v14.i7.1324]
Corresponding Author of This Article
Manju D Chandrasegaram, FRCS, MBChB, Attending Doctor, Senior Lecturer, Surgeon, Department of General Surgery, The Prince Charles Hospital, Rode Road, Brisbane 4032, Queensland, Australia. m.chandrasegaram@uq.edu.au
Research Domain of This Article
Surgery
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Jul 15, 2022; 14(7): 1324-1336 Published online Jul 15, 2022. doi: 10.4251/wjgo.v14.i7.1324
Effect of obesity on post-operative outcomes following colorectal cancer surgery
Derek Mao, David E Flynn, Stephanie Yerkovich, Kayla Tran, Usha Gurunathan, Manju D Chandrasegaram
Derek Mao, Faculty of Medicine and Health, The University of Sydney, Sydney 2050, New South Wales, Australia
David E Flynn, Manju D Chandrasegaram, Department of General Surgery, The Prince Charles Hospital, Brisbane 4032, Queensland, Australia
Stephanie Yerkovich, Usha Gurunathan, Manju D Chandrasegaram, Faculty of Medicine, The University of Queensland, Brisbane 4006, Queensland, Australia
Kayla Tran, Department of Pathology, The Prince Charles Hospital, Brisbane 4032, Queensland, Australia
Usha Gurunathan, Department of Anaesthesia, The Prince Charles Hospital, Brisbane 4032, Queensland, Australia
Author contributions: Mao D designed the study, performed the research, and wrote the manuscript; Flynn DE designed the study methodology and helped perform the research; Yerkovich S helped with data collection, statistical analysis, and manuscript review; Tran K and Gurunathan U helped with data collection, clinical advice, data analysis, and manuscript review; Chandrasegaram MD helped with design methodology and conceptualization, study supervision, manuscript editing and finalization.
Institutional review board statement: Ethics approval for this database was granted by the Prince Charles Hospital Human Research Ethics Committee (Approval No. HREC/17/QPCH/295).
Informed consent statement: I certify that patients were not required to give informed consent to the study because the analysis used anonymous clinical data that was obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Manju D Chandrasegaram, FRCS, MBChB, Attending Doctor, Senior Lecturer, Surgeon, Department of General Surgery, The Prince Charles Hospital, Rode Road, Brisbane 4032, Queensland, Australia. m.chandrasegaram@uq.edu.au
Received: November 22, 2021 Peer-review started: November 22, 2021 First decision: December 27, 2021 Revised: January 10, 2022 Accepted: June 18, 2022 Article in press: June 18, 2022 Published online: July 15, 2022 Processing time: 232 Days and 10.4 Hours
Core Tip
Core Tip: This retrospective study assessed the post-operative outcomes of obese patients undergoing colorectal cancer (CRC) resection. Despite having a greater burden of cardiovascular and respiratory comorbidities and increased rate of conversion to open surgery, obese patients had equitable post-operative outcomes as those with a normal body mass index. There were no differences in severity of complications, length of stay, or mortality rates. Comparisons of obese and non-obese patients undergoing laparoscopic surgery showed that obese patients had a higher prevalence of post-operative complications but not high-grade complications. CRC surgery in obese individuals is generally safe, with caution advised if a laparoscopic approach is planned.
