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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Mar 15, 2022; 14(3): 628-645
Published online Mar 15, 2022. doi: 10.4251/wjgo.v14.i3.628
Published online Mar 15, 2022. doi: 10.4251/wjgo.v14.i3.628
Clinical significance of molecular subtypes of gastrointestinal tract adenocarcinoma
Ekaterina Olegovna Ignatova, Mikhail Fedyanin, Alexey Tryakin, Ivan Stilidi, Department of Second Chemotherapy, Federal State Budgetary Institution “N.N. Blokhin National Medical Research Center of Oncology” of the Ministry of Health of the Russian Federation, Moscow 115478, Moscow, Russia
Ekaterina Olegovna Ignatova, Department of Oncogenetics, Research Centre for Medical Genetics Research Centre for Medical Genetics, Moscow 115522, Moscow, Russia
Evgenii Kozlov, Vladislav Mileyko, OncoAtlas LLC, Moscow 121069, Moscow, Russia
Maxim Ivanov, Department of Biological and Medical Physics, Moscow Institute of Physics and Technology, Moscow 141700, Moscow, Russia
Sofia Menshikova, Department of Anticancer Drug Treatment, AO K31 City, Moscow 121552, Moscow, Russia
Henian Sun, Pirogov Russian National Research Medical University (Pirogov Medical University), Moscow 117997, Moscow, Russia
Author contributions: Ignatova EO and Menshikova S drafted the manuscript; Kozlov E, Mileyko V, Ivanov M, and Sun H performed the literature search; Tryakin A, Fedyanin M and Ivan Stilidi critically reviewed the manuscript.
Conflict-of-interest statement: The authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ekaterina Olegovna Ignatova, MD, PhD, Associate Professor, Department of Second Chemotherapy, Federal State Budgetary Institution “N.N. Blokhin National Medical Research Center of Oncology” of the Ministry of Health of the Russian Federation, Kashirskoye Shosse 24, Moscow 115478, Moscow, Russia. md.ignatova@gmail.com
Received: March 10, 2021
Peer-review started: March 10, 2021
First decision: June 4, 2021
Revised: June 4, 2021
Accepted: February 25, 2022
Article in press: February 25, 2022
Published online: March 15, 2022
Peer-review started: March 10, 2021
First decision: June 4, 2021
Revised: June 4, 2021
Accepted: February 25, 2022
Article in press: February 25, 2022
Published online: March 15, 2022
Core Tip
Core Tip: Here we describe our opinion on molecular genetic subtyping of gastrointestinal adenocarcinomas (esophageal, gastric, and colon adenocarcinomas). The identification of combined molecular and genetic subtypes gave us insights to understanding gastrointestinal adenocarcinoma biology, determining aims for future clinical research, and helping to simplify the implementation of a unified system for subtyping gastrointestinal adenocarcinomas.