Review
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Mar 15, 2022; 14(3): 547-567
Published online Mar 15, 2022. doi: 10.4251/wjgo.v14.i3.547
Inflammatory bowel disease-related colorectal cancer: Past, present and future perspectives
Snehali Majumder, Uday Nagesh Shivaji, Rangarajan Kasturi, Alben Sigamani, Subrata Ghosh, Marietta Iacucci
Snehali Majumder, Alben Sigamani, Department of Clinical Research, Narayana Health, Bangalore 560099, Karnataka, India
Uday Nagesh Shivaji, Subrata Ghosh, Marietta Iacucci, National Institute for Health Research Birmingham Biomedical Research Centre, University Hospitals Birmingham, Birmingham B15 2TH, United Kingdom
Uday Nagesh Shivaji, Subrata Ghosh, Marietta Iacucci, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TH, United Kingdom
Rangarajan Kasturi, Department of Gastroenterology, Narayana Health, Bangalore 560099, India
Author contributions: Majumder S and Shivaji UN contributed literature search, data collection, data analysis, writing and editing manuscript, revision and final approval; Kasturi R, Sigamani A, Ghosh S and Iacucci M contributed writing and editing manuscript, revision and final approval.
Conflict-of-interest statement: The authors have none to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Uday Nagesh Shivaji, DSc, MBBS, MRCP, Senior Research Fellow, Staff Physician, National Institute for Health Research Birmingham Biomedical Research Centre, University Hospitals Birmingham, Mindelsohn Way, Birmingham B15 2TH, United Kingdom. u.n.shivaji@bham.ac.uk
Received: March 15, 2021
Peer-review started: March 15, 2021
First decision: April 6, 2021
Revised: April 21, 2021
Accepted: February 25, 2022
Article in press: February 25, 2022
Published online: March 15, 2022
Core Tip

Core Tip: The focus of the review is on the evolution of inflammatory bowel disease-related colorectal cancer (IBD-CRC) based on literature over the past decades to the present day. We provide a comprehensive overview of risk factors associated with IBD-CRC, molecular pathways identified and current strategies used to reduce incidence globally. We also touch upon the history of surveillance practice, its effectiveness, and the latest guidance on IBD surveillance by international societies. In a section on future directions, we discuss introduction of novel endoscopic technologies, artificial intelligence, and potential use of microbiota modulation, all of which could help reduce the risk of IBD-CRC.