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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Feb 15, 2022; 14(2): 525-532
Published online Feb 15, 2022. doi: 10.4251/wjgo.v14.i2.525
Published online Feb 15, 2022. doi: 10.4251/wjgo.v14.i2.525
Predictive value of serum alpha-fetoprotein for tumor regression after preoperative chemotherapy for rectal cancer
Da-Kui Zhang, Shao-Xuan Chen, Zhi-Yong Hou, Jian-Zheng Jie, Department of General Surgery, China-Japan Friendship Hospital, Beijing 100029, China
Jun Qiao, Department of General Surgery, Inner Mongolia International Mongolian Hospital, Hohhot 010020, Inner Mongolia Autonomous Region, China
Author contributions: Jie JZ and Zhang DK designed the research study; Qiao J, Chen SX and Hou ZY performed the research.
Supported by Youth Foundation of China–Japan Friendship Hospital , No. 2019-1-QN-42
Institutional review board statement: The study was reviewed and approved by the China-Japan Friendship Hospital Institutional Review Board, No. 2021-117-K75.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest to disclose.
Data sharing statement: No additional data are available.
STROBE statement: All authors have read the STROBE statement checklist of items. The manuscript was prepared and revised according to the STROBE statement checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Zheng Jie, MD, Doctor, Department of General Surgery, China-Japan Friendship Hospital, No. 2 Yinghuayuan East Street, Beijing 100029, China.
Received: August 12, 2021
Peer-review started: August 12, 2021
First decision: November 8, 2021
Revised: November 20, 2021
Accepted: January 19, 2022
Article in press: January 19, 2022
Published online: February 15, 2022
Processing time: 182 Days and 6.4 Hours
Peer-review started: August 12, 2021
First decision: November 8, 2021
Revised: November 20, 2021
Accepted: January 19, 2022
Article in press: January 19, 2022
Published online: February 15, 2022
Processing time: 182 Days and 6.4 Hours
Core Tip
Core Tip: We analyzed 125 patients with locally advanced rectal cancer retrospectively. The patients received 6 cycles of preoperative chemotherapy (mFOLFOX6 every 2 wk). Serum α-fetoprotein (AFP) of 26 patients rose slightly and returned to normal in two months. These patients achieved better tumor regression grade (TRG0-1) than those with normal AFP (61.5% vs 39.4%). Patients with a slight increase of serum AFP showed better tumor regression during preoperative chemotherapy, and were more likely to achieve pathological complete response (30.8% vs 12.1%).