Retrospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Dec 15, 2022; 14(12): 2367-2379
Published online Dec 15, 2022. doi: 10.4251/wjgo.v14.i12.2367
Evaluation of short-term effects of drug-loaded microspheres and traditional transcatheter arterial chemoembolization in the treatment of advanced liver cancer
Ting Ye, Shi-Han Shao, Kan Ji, Shu-Lin Yao
Ting Ye, Shu-Lin Yao, Department of Nuclear Medicine, First Medical Center, PLA General Hospital, Beijing 100039, China
Shi-Han Shao, Department of Hepatobiliary Surgery, The Sixth Medical Center, PLA General Hospital, Beijing 100048, China
Kan Ji, Department of Interventional Radiology, First Medical Center, PLA General Hospital, Beijing 100071, China
Author contributions: Ye T contributed to the research design and thesis writing; Shao SH collected and analyzed the data; Ji K contributed to the data collection; Yao SL overall supervise the study; and all authors proofed the revised manuscript.
Supported by National key research and development project of Ministry of Science and Technology, No. 2016YFC0103908.
Institutional review board statement: This study was approved by the First Medical Center, PLA General Hospital.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: No conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Shu-Lin Yao, MD, Associate Chief Technician, Statistical Worker, Department of Nuclear Medicine, First Medical Center, PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100039, China.
Received: August 1, 2022
Peer-review started: August 1, 2022
First decision: August 21, 2022
Revised: August 29, 2022
Accepted: November 16, 2022
Article in press: November 16, 2022
Published online: December 15, 2022
Core Tip

Core Tip: Hepatocellular carcinoma with a very high mortality rate is insidious and about 80 per cent of patients have no chance of surgery when diagnosed. Transcatheter arterial chemoembolization (TACE) is recommended as a first-line treatment. Traditional TACE uses iodized oil and gelatin sponge as the main embolization materials, and the chemotherapeutic drugs are mixed with iodized oil and injected into the tumor feeding artery to achieve the dual role of embolization and chemotherapy. Some scholars believe that liver cancer cells are not sensitive to chemotherapy drugs, so the role of chemotherapy drugs in TACE treatment is controversial. In recent years, drug-loaded microspheres have been gradually applied in TACE technology, which can significantly improve the killing effect of drugs on tumor tissues, and significantly reduce the systemic drug concentration, thereby reducing the side effects of chemotherapy drugs. In this study, the effects of using the same size of embolization particles and drug-eluting beads during TACE were compared. To investigate the effect and systemic response of chemotherapy drugs in TACE under the new local drug delivery mode.