Prospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2022; 14(10): 2048-2060
Published online Oct 15, 2022. doi: 10.4251/wjgo.v14.i10.2048
Long-term follow-up of HER2 overexpression in patients with rectal cancer after preoperative radiotherapy: A prospective cohort study
Nan Chen, Chang-Long Li, Yi-Fan Peng, Yun-Feng Yao
Nan Chen, Chang-Long Li, Yi-Fan Peng, Yun-Feng Yao, Department of Gastrointestinal Surgery, Ward III, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing 100142, China
Author contributions: Chen N and Li CL contributed equally to this paper; Chen N and Li CL drafted the manuscript; Chen N, Peng YF and Yao YF designed this study.
Supported by Beijing Municipal Administration of Hospitals Incubating Program, No. PZ2020027; and Beijing Talent Incubating Funding, No. 2019-4.
Institutional review board statement: The study was reviewed and approved by the Beijing Cancer Hospital Institutional Review Board (approval No. 2015KT33).
Clinical trial registration statement: This study is registered at Clinical trial registry of Beijing Cancer Hospital. The registration identification number is 2015KT33.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nan Chen, MD, PhD, Associate Professor, Department of Gastrointestinal Surgery, Ward III, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, China. chennanpku@126.com
Received: March 1, 2022
Peer-review started: March 1, 2022
First decision: April 19, 2022
Revised: May 17, 2022
Accepted: August 24, 2022
Article in press: August 24, 2022
Published online: October 15, 2022
Processing time: 227 Days and 2.6 Hours
Core Tip

Core Tip: Long-term follow-up of rectal cancer patients treated with neoadjuvant radiotherapy demonstrated that pre-treatment HER2 overexpression was significantly correlated with lymph node metastasis and long-term distant metastasis. Furthermore, HER2 overexpression, elevated CEA and lymph node positivity were independent risk factors, predictive for poorer survival.