Feng ML, Wu C, Zhang HJ, Zhou H, Jiao TW, Liu MY, Sun MJ. Overexpression of ELL-associated factor 2 suppresses invasion, migration, and angiogenesis in colorectal cancer. World J Gastrointest Oncol 2022; 14(10): 1949-1967 [PMID: 36310706 DOI: 10.4251/wjgo.v14.i10.1949]
Corresponding Author of This Article
Ming-Jun Sun, Doctor, PhD, Chief Physician, Professor, Department of Endoscopy, The First Hospital Affiliated to China Medical University, No. 155 Nanjing North Street, Shenyang 110001, Liaoning Province, China. sunydyy@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Oct 15, 2022; 14(10): 1949-1967 Published online Oct 15, 2022. doi: 10.4251/wjgo.v14.i10.1949
Overexpression of ELL-associated factor 2 suppresses invasion, migration, and angiogenesis in colorectal cancer
Ming-Liang Feng, Can Wu, Hui-Jing Zhang, Huan Zhou, Tai-Wei Jiao, Meng-Yuan Liu, Ming-Jun Sun
Ming-Liang Feng, Can Wu, Hui-Jing Zhang, Huan Zhou, Tai-Wei Jiao, Meng-Yuan Liu, Ming-Jun Sun, Department of Endoscopy, The First Hospital Affiliated to China Medical University, Shenyang 110001, Liaoning Province, China
Author contributions: Feng ML and Wu C designed the research study; Zhang HJ and Jiao TW performed the research; Zhou H and Liu MY contributed new reagents and analytic tools; Feng ML and Sun MJ analyzed the data and wrote the manuscript; and all authors have read and approved the final manuscript.
Supported bythe Natural Science Foundation of Liaoning Province, No. 2019-BS-279.
Institutional review board statement: This study was approved by the Institutional Review Board of The First Affiliated Hospital of China Medical University (Registration No. 2021-68-2).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ming-Jun Sun, Doctor, PhD, Chief Physician, Professor, Department of Endoscopy, The First Hospital Affiliated to China Medical University, No. 155 Nanjing North Street, Shenyang 110001, Liaoning Province, China. sunydyy@163.com
Received: May 19, 2022 Peer-review started: May 19, 2022 First decision: June 6, 2022 Revised: June 20, 2022 Accepted: September 21, 2022 Article in press: September 21, 2022 Published online: October 15, 2022 Processing time: 147 Days and 20.6 Hours
Core Tip
Core Tip: Androgen-responsive gene ELL-associated factor 2 (EAF2) plays an important role in tumor suppression in a variety of malignant tumors. We found that EAF2 protein was lowly expressed in colorectal cancer (CRC) tissues. Kaplan-Meier survival analysis showed that the survival rate of the group with high EAF2 level was higher than that of the group with low EAF2 level. Moreover, EAF2 may play a tumor suppressive and protective role in CRC by inhibiting the invasion, metastasis, and angiogenesis via regulating the signal transducer and activator of transcription 3/transforming growth factor beta 1 crosstalk pathway. Our findings are of great significance to provide a new idea and theoretical basis for targeting diagnosis and therapy of CRC.
