Basic Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2022; 14(10): 1918-1932
Published online Oct 15, 2022. doi: 10.4251/wjgo.v14.i10.1918
Transcriptional factor III A promotes colorectal cancer progression by upregulating cystatin A
Jing Wang, Yuan Tan, Qun-Ying Jia, Fa-Qin Tang
Jing Wang, Yuan Tan, Qun-Ying Jia, Fa-Qin Tang, Hunan Key Laboratory of Oncotarget Gene, Hunan Cancer Hospital & The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, Hunan Province, China
Author contributions: Tang FQ designed and coordinated the study; Wang J, Tan Y, and Jia QY performed the experiments, and acquired and analyzed data; Wang J and Tang FQ wrote the manuscript; and all authors approved the final version of the article.
Supported by the National Natural Science Foundation of China, No. 81872226; Changsha Science and Technology Project, No. 2019TP1046; and the Research Projects of Hunan Health Commission, No. B2019084.
Institutional review board statement: The study was reviewed and approved by the Hunan Cancer Hospital Institutional Review Board (Approval No. KYJJ-2020-004).
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Hunan Cancer Hospital (No. 2020-118).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fa-Qin Tang, MD, PhD, Doctor, Professor, Hunan Key Laboratory of Oncotarget Gene, Hunan Cancer Hospital & The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, No. 283 Tongzipo Road, Changsha 410013, Hunan Province, China. tangfq@hnca.org.cn
Received: May 7, 2022
Peer-review started: May 7, 2022
First decision: July 13, 2022
Revised: July 23, 2022
Accepted: September 8, 2022
Article in press: September 8, 2022
Published online: October 15, 2022
Processing time: 160 Days and 9.1 Hours
Core Tip

Core Tip: Transcriptional factor III A (GTF3A) is highly expressed in colorectal cancer (CRC) tissues, and GTF3A expression is associated with CRC prognosis. GTF3A binds to the promoter of cystatin (Csta) gene to facilitate Csta transcription, which regulates the expression of epithelial-mesenchymal transition markers and promotes CRC progression. Blocking GTF3A significantly inhibits CRC cell growth. Therefore, GTF3A is a potential novel therapeutic target and prognostic biomarker for CRC.