Review
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World J Gastrointest Oncol. Jan 15, 2022; 14(1): 90-109
Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.90
Gastric cancer: An epigenetic view
Si-Yuan Tang, Pei-Jun Zhou, Yu Meng, Fu-Rong Zeng, Guang-Tong Deng
Si-Yuan Tang, Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
Pei-Jun Zhou, Cancer Research Institute, School of Basic Medicine Science, Central South University, School of Basic Medicine Science, Central South University 410008, Hunan Province, China
Yu Meng, Fu-Rong Zeng, Guang-Tong Deng, Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
Author contributions: Deng GT, Zeng FR, and Tang SY designed the study; Tang SY and Zeng FR wrote the manuscript; Zhou PJ and Meng Y revised the manuscript; All the authors supported the study.
Supported by The fellowship of the China Postdoctoral Science Foundation, No. 2020M682594.
Conflict-of-interest statement: All authors have no any conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guang-Tong Deng, MD, Doctor, Department of Dermatology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha 410008, Hunan Province, China. dengguangtong@outlook.com
Received: March 21, 2021
Peer-review started: March 21, 2021
First decision: May 3, 2021
Revised: May 17, 2021
Accepted: December 21, 2021
Article in press: December 21, 2021
Published online: January 15, 2022
Processing time: 295 Days and 11.4 Hours
Core Tip

Core Tip: Epigenetics plays a vital role in gastric carcinogenesis and progression. In this review, key epigenetic alterations and related functions and mechanisms are summarized in gastric cancer.