Review
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jan 15, 2022; 14(1): 55-74
Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.55
Effects of Helicobacter pylori infection in gastrointestinal tract malignant diseases: From the oral cavity to rectum
Yang-Che Kuo, Lo-Yip Yu, Horng-Yuan Wang, Ming-Jen Chen, Ming-Shiang Wu, Chun-Jen Liu, Ying-Chun Lin, Shou-Chuan Shih, Kuang-Chun Hu
Yang-Che Kuo, Horng-Yuan Wang, Ming-Jen Chen, Division of Gastroenterology, Department of Internal Medicine, MacKay Memorial Hospital, Taipei 10449, Taiwan
Lo-Yip Yu, Department of Internal Medicine, Healthy Evaluation Center, Mackay Memorial Hospital, Taipei 10449, Taiwan
Ming-Shiang Wu, Department of Internal Medicine, National Taiwan University Hospital, Taipei 10051, Taiwan
Chun-Jen Liu, Department of Internal Medicine, Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei 10051, Taiwan
Ying-Chun Lin, Department of Anesthesia, MacKay Memorial Hospital, Taipei 10449, Taiwan
Shou-Chuan Shih, Division of Gastroenterology, Department of Internal Medicine, Health Evaluate Center, Mackay Memorial Hospital, Taipei 10449, Taiwan
Kuang-Chun Hu, Department of Internal Medicine, Healthy Evaluation Center, Mackay Memorial Hospital, MacKay Junior College of Medicine, Nursing, and Management, Taipei 10038, Taiwan
Author contributions: Wang HY, Chen MJ, Wu MS, Liu CJ, Lin YC and Shih SC performed literature research; Kuo YC, Yu LY, Lin YC and Hu KC wrote the manuscript and performed the revision and approval of the final version; Hu KC designed research, coordinated and corrected the writing of the paper.
Supported by 108DMH0100146 and 108WHK0910031.
Conflict-of-interest statement: The authors deny any conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kuang-Chun Hu, MD, PhD, Attending Doctor, Department of Internal Medicine, Healthy Evaluation Center, Mackay Memorial Hospital, MacKay Junior College of Medicine, Nursing, and Management, No. 92, Sec. 2, Chung-Shan North Road, Taipei 10038, Taiwan. mimiandbear2001@yahoo.com.tw
Received: March 7, 2021
Peer-review started: March 7, 2021
First decision: April 19, 2021
Revised: May 3, 2021
Accepted: December 9, 2021
Article in press: December 9, 2021
Published online: January 15, 2022
Core Tip

Core Tip: Helicobacter pylori (H. pylori) has infected approximately fifty percent of humans for a long period of time. However, improvements in the public health environment have led to a decreased chance of H. pylori infection. This review article provides an overview of the correlation of H. pylori infection and gastrointestinal tract malignant diseases. Based on data on H. pylori, we believe that the digestive tract microenvironment and H. pylori motility affect the risk of cancer formation by H. pylori infection.