Intertwined leukocyte balances in tumours and peripheral blood as robust predictors of right and left colorectal cancer survival
Ramón Cantero-Cid, Karla Marina Montalbán-Hernández, Alejandro Pascual-Iglesias, Elisa Pulido, José Carlos Casalvilla, Jaime Valentín, Gloria Cristina Bonel-Pérez, José Avendaño-Ortiz, Verónica Terrón, Roberto Lozano-Rodríguez, Elvira Marín, Eduardo López-Collazo, Luis Augusto Aguirre, Tumor Immunology Laboratory, The Innate Immune Response Group, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid 28046, Spain
Jenny Guevara, Cristóbal Marcano, Cristina Barragán Serrano, Digestive Surgery Service, La Paz University Hospital, Madrid 28046, Spain
Alejandro Martín-Quirós, Emergency Department and Emergent Pathology Research Group, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid 28046, Spain
Eva Pena, Laura Guerra-Pastrián, Pathologic Anatomy Service, Hospital La Paz, Madrid 28046, Spain
Author contributions: Cantero-Cid R and Montalbán-Hernández KM contributed equally to the manuscript; Cantero-Cid R participated in the design of the study and performed patient recruitment, surgery, and sample collection; Montalbán-Hernández KM performed sample collection, assisted with sample analysis, and performed image analysis; Pulido E performed sample analysis and assisted with image analysis; Pascual-Iglesias A performed statistical analysis; Casalvilla JC assisted with sample analysis and with image analysis; Valentín J assisted with sample analysis and with image analysis; Bonel-Pérez GC assisted with sample analysis and with image analysis; Avendaño-Ortiz J assisted with sample analysis; Terrón V assisted with sample analysis; Lozano-Rodríguez R assisted with sample analysis; Martín-Quirós A participated in patient recruitment; Marín E performed sample analysis; Guevara J participated in patient recruitment, surgery, sample collection, and assisted with data analysis; Marcano C participated in patient recruitment, surgery, sample collection, and assisted with data analysis; Barragán C participated in patient recruitment, surgery, and sample collection; Pena E was involved with sample collection and assisted with anatomo-pathological analyses; Guerra-Pastrián L was involved with sample collection and performed anatomo-pathological analyses; López-Collazo E participated in the design and oversight of the study and drafted the manuscript; Aguirre LA designed and supervised the study, assisted with data analysis, and drafted the manuscript; all authors read and approved the final manuscript.
Supported by the Foundation for the Hospital La Paz Institute for Health Research, No. PI698; Fundación Familia Alonso; Fundación Antolín Garcíarena and the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowaska-Curie-’laCaixa’, No. 713673.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee for Clinical Research of the La Paz University Hospital (Madrid, Spain). Access number: PI-1958.
Informed consent statement: All study participants, or their legal guardian, provided written consent prior to study enrolment.
Conflict-of-interest statement: The authors of this manuscript have no conflicts of interest to disclose.
Data sharing statement: There is no additional data available.
: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Luis Augusto Aguirre, PhD, Senior Researcher, Tumor Immunology Laboratory, The Innate Immune Response Group, Hospital La Paz Institute for Health Research (IdiPAZ), Paseo de la Castellana, 261, Madrid 28046, Spain. email@example.com
Received: May 16, 2021
Peer-review started: May 16, 2021
First decision: June 16, 2021
Revised: August 7, 2021
Accepted: November 30, 2021
Article in press: November 30, 2021
Published online: January 15, 2022