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World J Gastrointest Oncol. Jan 15, 2022; 14(1): 1-18
Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.1
Molecular regulatory mechanism of ferroptosis and its role in gastrointestinal oncology: Progress and updates
Fan Yang, Si-Yu Sun, Sheng Wang, Jin-Tao Guo, Xiang Liu, Nan Ge, Guo-Xin Wang
Fan Yang, Si-Yu Sun, Sheng Wang, Jin-Tao Guo, Xiang Liu, Nan Ge, Guo-Xin Wang, Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Author contributions: Yang F wrote the paper; Sun SY, Wang S, Guo JT, Liu X, Ge N, and Wang GX collected the data.
Supported by China Postdoctoral Science Foundation, No. 2020M670101ZX; Doctoral Scientific Research Foundation of Liaoning Province, No. 2019-BS-276; Science and Technology Program of Shenyang, No. 19-112-4-103; Youth Support Foundation of China Medical University, No. QGZ2018058; Scientific Fund of Shengjing Hospital, No. 201801; and 345 Talent Project of Shengjing Hospital, No. 52-30C.
Conflict-of-interest statement: The authors have no conflict of interests to declare for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Si-Yu Sun, MD, PhD, Chief Doctor, Doctor, Professor, Department of Gastroenterology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110004, Liaoning Province, China. sun-siyu@163.com
Received: April 20, 2021
Peer-review started: April 20, 2021
First decision: July 29, 2021
Revised: August 4, 2021
Accepted: December 7, 2021
Article in press: December 7, 2021
Published online: January 15, 2022
Core Tip

Core Tip: Ferroptosis refers to cell death triggered by iron-dependent lipid peroxidation. Recent studies have demonstrated that ferroptosis is involved in the onset and progression of numerous gastrointestinal (GI) tumors. Hence, inducing ferroptosis in tumor cells may become a new therapeutic strategy against GI tumors. Here, we review the molecular mechanism of ferroptosis and its role in GI tumors, with the aim of providing new research directions and ideas for the treatment of GI tumors.