Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Sep 15, 2021; 13(9): 1043-1061
Published online Sep 15, 2021. doi: 10.4251/wjgo.v13.i9.1043
Neoadjuvant chemotherapy for colorectal liver metastases: A contemporary review of the literature
Marissa Guo, Ning Jin, Timothy Pawlik, Jordan M Cloyd
Marissa Guo, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210, United States
Ning Jin, Department of Internal Medicine, Division of Medical Oncology, The Ohio State University Medical Center, Columbus, OH 43210, United States
Timothy Pawlik, Department of Surgery, The Ohio State University, Columbus, OH 43210, United States
Jordan M Cloyd, Department of Surgery, Division of Surgical Oncology, The Ohio State University Medical Center, Columbus, OH 43210, United States
Author contributions: Guo M performed the literature review, collated data on the manuscript topic, and took the lead in writing the manuscript; Jin N and Pawlik T provided clinical expertise and critical feedback; Cloyd JM conceived and planned the outline of the review article, provided clinical expertise, and wrote significant portions of the manuscript.
Conflict-of-interest statement: Authors report no conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jordan M Cloyd, MD, Assistant Professor, Department of Surgery, Division of Surgical Oncology, The Ohio State University Medical Center, N907 Doan Hall, 410 W 10th Ave, Columbus, OH 43210, United States. jordan.cloyd@osumc.edu
Received: March 16, 2021
Peer-review started: March 16, 2021
First decision: May 3, 2021
Revised: May 17, 2021
Accepted: August 6, 2021
Article in press: August 6, 2021
Published online: September 15, 2021
Processing time: 177 Days and 16.9 Hours
Core Tip

Core Tip: Colorectal carcinoma is one of the leading causes of cancer-related deaths worldwide. Neoadjuvant chemotherapy is an important treatment strategy for patients with colorectal liver metastases that can downstage tumors and facilitate hepatic resection. Although its use in patients with initially resectable disease is controversial, it is currently recommended for those with unresectable to borderline resectable metastases.