Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Sep 15, 2021; 13(9): 1029-1042
Published online Sep 15, 2021. doi: 10.4251/wjgo.v13.i9.1029
Real-time fluorescence image-guided gastrointestinal oncologic surgery: Towards a new era
Elías Martínez-López, Aleix Martínez-Pérez, Sergio Navarro-Martínez, Juan Carlos Sebastián-Tomás, Nicola de'Angelis, Eduardo García-Granero
Elías Martínez-López, Juan Carlos Sebastián-Tomás, Eduardo García-Granero, Department of Surgery, University of Valencia, Valencia 46010, Spain
Elías Martínez-López, Sergio Navarro-Martínez, Juan Carlos Sebastián-Tomás, Department of General and Digestive Surgery, Hospital Universitario Doctor Peset, Valencia 46017, Spain
Aleix Martínez-Pérez, Faculty of Health Sciences, Valencian International University, Valencia 46002, Spain
Aleix Martínez-Pérez, Nicola de'Angelis, Minimally Invasive and Robotic Digestive Surgery Unit, Miulli Hospital, Acquaviva delle Fonti 70021, Italy
Eduardo García-Granero, Department of General and Digestive Surgery, Hospital Universitario y Politécnico La Fe, Valencia 46026, Spain
Author contributions: Martínez-López E, Martínez-Pérez A and García-Granero E contributed to conception and design of the work; all authors contributed to drafting of the manuscript and critical revision for important intellectual content; All authors approved the final version.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Aleix Martínez-Pérez, MD, PhD, Faculty of Health Sciences, Valencian International University, Pintor Sorolla 21, Valencia 46002, Spain.
Received: February 22, 2021
Peer-review started: February 22, 2021
First decision: June 14, 2021
Revised: June 14, 2021
Accepted: July 27, 2021
Article in press: July 27, 2021
Published online: September 15, 2021
Core Tip

Core Tip: The continuous improvements on the postoperative and the oncological outcomes of patients undergoing gastrointestinal cancer surgery has focused the efforts of the whole surgical community during the last decades. Fluorescence-guided surgery is currently being developed and implemented in many countries and centers with promising expectancies. Fluorescence-guided surgery has the potential to reduce anastomotic leak rates of colorectal or esophagogastric surgery. Moreover, this new technology provides intraoperative real-time lymph node mapping and detection of sentinel lymph nodes or occult peritoneal metastases.