Observational Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Aug 15, 2021; 13(8): 970-979
Published online Aug 15, 2021. doi: 10.4251/wjgo.v13.i8.970
Diagnostic value of four serum exosome microRNAs panel for the detection of colorectal cancer
Lei Han, Wen-Jie Shi, Yi-Bin Xie, Zhi-Guo Zhang
Lei Han, Zhi-Guo Zhang, Department of Oncology, Beijing Daxing District People’s Hospital, Beijing 102600, China
Wen-Jie Shi, Department of Medicine Innovation Research, Chinese PLA General Hospital, Beijing 100853, China
Yi-Bin Xie, Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100121, China
Author contributions: Han L, Xie YB, and Zhang ZG and designed the study; Han L and Xie YB performed the research; Shi WJ analyzed the data; Han L wrote the paper; Xie YB and Shi WJ revised the manuscript for final submission; Han L and Shi WJ contributed equally to this study.
Supported by CAMS Initiative for Innovative Medicine, No. 2016-I2M-1-007; National Key Research and Development Program of China, No. 2020YFC2004604; National Natural Science Foundation of China, No. 81972010.
Institutional review board statement: The study was reviewed and approved by the Beijing Daxing District People’s Hospital review board.
Informed consent statement: All study participants or their legal guardian provided written informed consent prior to study enrollment.
Conflict-of-interest statement: No conflict of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Guo Zhang, MD, Doctor, Department of Oncology, Beijing Daxing District People’s Hospital, No. 26 Huangcun West Street, Beijing 102600, China. zhangzhiguo555888@163.com
Received: June 10, 2021
Peer-review started: June 10, 2021
First decision: June 15, 2021
Revised: June 18, 2021
Accepted: July 5, 2021
Article in press: July 5, 2021
Published online: August 15, 2021
Processing time: 65 Days and 2.3 Hours
Core Tip

Core Tip: In this study, we aimed to evaluate the diagnostic value of colorectal cancer by detecting the exosome four microRNAs (miR-15b, miR-16, miR-21, miR-31). The diagnostic model may serve as a novel diagnostic model for colorectal cancer.