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World J Gastrointest Oncol. Aug 15, 2021; 13(8): 856-866
Published online Aug 15, 2021. doi: 10.4251/wjgo.v13.i8.856
Young-onset colorectal cancer: A review
Joy Zhou Done, Sandy H Fang
Joy Zhou Done, Department of Surgery, Johns Hopkins Hospital, Baltimore, MD 21287, United States
Sandy H Fang, Department of Surgery, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, United States
Author contributions: Done JZ and Fang SH contributed equally to this work; Done JZ and Fang SH performed independent literature searches for this systematic review, analyzed the literature/data, and wrote the manuscript; all authors have read and approve the final manuscript.
Conflict-of-interest statement: Neither Dr. Done JZ nor Dr. Fang SH have any conflicts of interest to disclose for this paper.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sandy H Fang, MD, Surgeon, Department of Surgery, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, 600 North Wolfe Street, Ravitch Division of Colon and Rectal Surgery, Blalock 618, Baltimore, MD 21287, United States. sfang7@jhmi.edu
Received: February 21, 2021
Peer-review started: February 21, 2021
First decision: April 19, 2021
Revised: April 30, 2021
Accepted: July 19, 2021
Article in press: July 19, 2021
Published online: August 15, 2021
Processing time: 174 Days and 1.1 Hours
Core Tip

Core Tip: Despite the overall decreasing incidence of colorectal cancer, the incidence of young-onset colorectal cancer is on the rise. Identifying genetic, molecular, clinical, behavioral patient characteristics of this subset population is vital in the timely diagnosis and customized management of these patients.