Minireviews
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. May 15, 2021; 13(5): 366-390
Published online May 15, 2021. doi: 10.4251/wjgo.v13.i5.366
Molecular-targeted therapy toward precision medicine for gastrointestinal cancer: Current progress and challenges
Tasuku Matsuoka, Masakazu Yashiro
Tasuku Matsuoka, Masakazu Yashiro, Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan
Author contributions: Matsuoka T and Yahiro M performed literature research; Matsuoka T wrote the manuscript and performed the revision and approval of the final version; Yahiro M designed research, coordinated and corrected the writing of the paper.
Supported by KAKENHI (Grant-in-Aid for Scientific Research), No. 18H02883.
Conflict-of-interest statement: There are not any financial or other interests regarding the submitted manuscript that might be construed as a conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Masakazu Yashiro, MD, PhD, Associate Professor, Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. m9312510@med.osaka-cu.ac.jp
Received: January 14, 2021
Peer-review started: January 14, 2021
First decision: February 14, 2021
Revised: March 4, 2021
Accepted: April 21, 2021
Article in press: April 21, 2021
Published online: May 15, 2021
Core Tip

Core Tip: Outcomes in metastatic gastrointestinal (GI) cancer are improving with the better understanding and use of targeted therapies. Herein, a review of the literature and recent conference presentations was conducted regarding the topic of targeted therapies for precision medicine in GI cancer. This article clarifies the current evidence for targeted therapies in GI cancer by evaluating the latest data regarding anti- epidermal growth factor receptor, human epidermal growth factor receptor 2, vascular endothelial growth factor, phosphatidylinositol-3-hydroxykinase/protein kinase B, tumor growth factor-β, mesenchymal-epithelial transition, wireless network technology, poly (ADP-ribose) polymerase, and immunotherapies.