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World J Gastrointest Oncol. Nov 15, 2021; 13(11): 1680-1695
Published online Nov 15, 2021. doi: 10.4251/wjgo.v13.i11.1680
Liver tumors in children with chronic liver diseases
Palittiya Sintusek, Teerasak Phewplung, Anapat Sanpavat, Yong Poovorawan
Palittiya Sintusek, Thai Pediatric Gastroenterology, Hepatology and Immunology Research Unit, Department of Pediatrics, Division of Gastroenterology, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok 10330, Thailand
Teerasak Phewplung, Department of Radiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand
Anapat Sanpavat, Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
Yong Poovorawan, Center of Excellence in Clinical Virology, Chulalongkorn University, Bangkok 10330, Thailand
Author contributions: Sintusek P reviewed the literature and wrote the manuscript; Phewplung T prepared, interpreted the imaging study, and provided the liver tumor images; Sanpavat A interpreted and prepared the histopathology images; Poovorawan Y edited the intellectual content in the manuscript; All authors approved the final manuscript.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Palittiya Sintusek, MD, MSc, Associate Professor, Thai Pediatric Gastroenterology, Hepatology and Immunology Research Unit, Chulalongkorn University, 1873, Rama 4 Road, Pathumwan, Bangkok 10330, Thailand. palittiya.s@chula.ac.th
Received: March 1, 2021
Peer-review started: March 1, 2021
First decision: April 19, 2021
Revised: April 27, 2021
Accepted: August 23, 2021
Article in press: August 23, 2021
Published online: November 15, 2021
Processing time: 255 Days and 19.1 Hours
Core Tip

Core Tip: Liver tumors in children are rare, although children with underlying chronic liver diseases may present a higher risk. Early detection and timely management lead to a good prognosis and outcome. Recently, contrast enhanced ultrasound has been the preferred modality for surveillance to identify and classify the etiology of liver tumors. As the more frequent liver tumors in children with chronic liver diseases are mainly malignant, liver transplant should be considered as the first option to achieve favorable results. In addition, regular assessment is necessary in asymptomatic benign liver tumors with the potential for malignant transformation.