Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. May 15, 2020; 12(5): 559-568
Published online May 15, 2020. doi: 10.4251/wjgo.v12.i5.559
Perioperative chemotherapy for advanced gastric cancer - results from a tertiary-care hospital in Germany
Katrin Bauer, Giulia Manzini, Doris Henne-Bruns, Peter Buechler
Katrin Bauer, Peter Buechler, Department for General, Visceral, Thoracic and Paediatric Surgery, Clinic of Kempten, Kempten 87439, Germany
Giulia Manzini, Doris Henne-Bruns, Department of General and Visceral Surgery, University Hospital of Ulm, Ulm 89081, Germany
Author contributions: Bauer K and Manzini G contributed equally to this work; Bauer K, Manzini G, Henne-Bruns D and Buechler P designed the research; Bauer K, Manzini and Buechler P performed the research; Bauer K, Manzini G and Henne-Bruns D analysed the data; Manzini G worked out the statistics; Bauer K, Manzini G and Henne-Bruns D wrote the paper; Bauer K and Manzini G are responsible for the final approval of the paper.
Institutional review board statement: According to consultation with the Federal Medical Association the institutional review board stated that it was not necessary to obtain a decision by the Ethics Commission for this retrospective analysis of our internal hospital data.
Informed consent statement: For the analysis of our internal hospital data an informed consent statement was not necessary.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Katrin Bauer, MD, Doctor, Surgeon, Department for General, Visceral, Thoracic and Paediatric Surgery, Clinic of Kempten, Robert-Weixler Strasse 50, Kempten 87439, Germany.
Received: November 27, 2019
Peer-review started: November 27, 2019
First decision: December 26, 2019
Revised: March 18, 2020
Accepted: April 8, 2020
Article in press: April 8, 2020
Published online: May 15, 2020
Core Tip

Core tip: Due to the unfavourable prognosis of locally advanced gastric carcinoma, multimodal therapy has been propagated worldwide in the last decade. European guidelines recommend perioperative chemotherapy on the basis of a few randomized trials, which are of limited validity for certain reasons. These studies had shown a better 5-year overall survival of approximately 15%, but neither the studies nor guidelines focused on the age and tumour localization of the patients. The goal of our study was to compare the observed effects of randomized controlled studies with real life data from a German community hospital with a focus on patient age and tumour localization.