Retrospective Cohort Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. May 15, 2020; 12(5): 549-558
Published online May 15, 2020. doi: 10.4251/wjgo.v12.i5.549
Neutropenia in colorectal cancer treated with oxaliplatin-based hyperthermic intraperitoneal chemotherapy: An observational cohort study
Peter H Cashin, Lana Ghanipour, Malin Enblad, David L Morris
Peter H Cashin, Lana Ghanipour, Malin Enblad, Department of Surgical Sciences, Section of Surgery, Uppsala University, Akademiska Sjukhuset, Uppsala 75185, Sweden
David L Morris, Department of Surgery, University of New South Wales, Sydney 2217, New South Wales, Australia
Author contributions: Cashin PH designed research and wrote the paper; Cashin PH, Ghanipour L, Enblad M and Morris DL did data acquisition, data interpretation, manuscript editing for intellectual content.
Institutional review board statement: The study was reviewed and approved for publication by the Uppsala County Ethical Review Board.
Informed consent statement: No informed consent was required by the ethical review board due to the retrospective nature of the study and the anonymous data used for the study.
Conflict-of-interest statement: All the authors have no conflict of interest related to the manuscript.
Data sharing statement: The original anonymous dataset is available on request from the corresponding author at
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Peter H Cashin, MD, PhD, Director, Surgeon, Department of Surgical Sciences, Uppsala University, Akademiska Sjukhuset, Uppsala 75185, Sweden.
Received: February 3, 2020
Peer-review started: February 3, 2020
First decision: February 25, 2020
Revised: April 14, 2020
Accepted: April 24, 2020
Article in press: April 24, 2020
Published online: May 15, 2020
Core Tip

Core tip: We investigated neutropenia after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) treatment of colorectal cancer with peritoneal metastases. The frequency of neutropenia was 13%; however, it was much more common in the oxaliplatin + irinotecan HIPEC treatment than in the single oxaliplatin HIPEC treatment. Neutropenia did not increase the risk of Clavien-Dindo morbidity. Furthermore, it was found to be an independent prognostic factor for disease-free survival. In conclusion, we found that neutropenia doesn’t appear to be a toxicity limiting factor as it does not increase the postoperative morbidity, but rather a positive prognostic factor that may predict a better outcome.