Chen PJ, Wang L, Peng YF, Chen N, Wu AW. Surgical intervention for malignant bowel obstruction caused by gastrointestinal malignancies. World J Gastrointest Oncol 2020; 12(3): 323-331 [PMID: 32206182 DOI: 10.4251/wjgo.v12.i3.323]
Corresponding Author of This Article
Ai-Wen Wu, MD, PhD, Full Professor, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Cancer Center, Unit III, Peking University Cancer Hospital and Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, China. wuaw@sina.com
Research Domain of This Article
Surgery
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Mar 15, 2020; 12(3): 323-331 Published online Mar 15, 2020. doi: 10.4251/wjgo.v12.i3.323
Surgical intervention for malignant bowel obstruction caused by gastrointestinal malignancies
Peng-Ju Chen, Lin Wang, Yi-Fan Peng, Nan Chen, Ai-Wen Wu
Peng-Ju Chen, Lin Wang, Yi-Fan Peng, Nan Chen, Ai-Wen Wu, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Cancer Center, Unit III, Peking University Cancer Hospital and Institute, Beijing 100142, China
Author contributions: Chen PJ, Wang L and Peng YF contributed equally to this work; Chen PJ and Wang L designed research; Peng YF performed research; Chen N analyzed data; Chen PJ, Peng YF and Wu AW wrote the paper.
Supported byNational Natural Science Foundation of China, No. 81773214.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Peking University Cancer Hospital and Institute, approval No. 2019YJZ46.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data.
Conflict-of-interest statement: The authors have nothing to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ai-Wen Wu, MD, PhD, Full Professor, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Cancer Center, Unit III, Peking University Cancer Hospital and Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, China. wuaw@sina.com
Received: September 27, 2019 Peer-review started: September 27, 2019 First decision: November 18, 2019 Revised: November 27, 2019 Accepted: January 14, 2020 Article in press: January 14, 2020 Published online: March 15, 2020 Processing time: 167 Days and 4.1 Hours
Core Tip
Core tip: Malignant bowel obstruction (MBO) is a frequent event for patients with end-stage gastrointestinal cancer. There is no consensus on the optimal treatment strategy for improving quality of life and prolonging survival. We performed a retrospective study at a single institution to determine the effects of palliative surgery for MBO in patients with gastrointestinal cancers. In this cohort, we observed higher symptom relief rates and prolonged survival after massive debulking surgery compared with ostomy/by-pass surgery in MBO patients. For select patients with MBO caused by metastatic colorectal cancer, massive debulking surgery can result in higher symptom palliation rates and prolonged survival without increasing mortality and morbidity rates compared with ostomy/by-pass surgery.
