Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Mar 15, 2020; 12(3): 301-310
Published online Mar 15, 2020. doi: 10.4251/wjgo.v12.i3.301
Circulating cytokines and outcome in metastatic colorectal cancer patients treated with regorafenib
Vincenzo Ricci, Cristina Granetto, Antonella Falletta, Matteo Paccagnella, Andrea Abbona, Elena Fea, Teresa Fabozzi, Cristiana Lo Nigro, Marco Carlo Merlano
Vincenzo Ricci, Cristina Granetto, Elena Fea, Marco Carlo Merlano, Medical Oncology and Laboratory of Translational Oncology, Oncology Department, S. Croce and Carle Teaching Hospital Cuneo, Cuneo 12100, Italy
Antonella Falletta, Matteo Paccagnella, Andrea Abbona, Marco Carlo Merlano, Arco Cuneo Foundation, Cuneo 12100, Italy
Teresa Fabozzi, Medical Oncology, S. G. Bosco Hospital, Torino 10154, Italy
Cristiana Lo Nigro, Laboratory, S. Croce and Carle Teaching Hospital Cuneo, Cuneo 12100, Italy
Author contributions: Ricci V and Merlano MC designed the research; Ricci V, Granetto C and Fea E enrolled the patients; Fabozzi T, Granetto C and Lo Nigro C revised the manuscript; Falletta A, Paccagnella M and Abbona A performed the research; Lo Nigro C collected the samples; Falletta A, Ricci V and Fabozzi T wrote the paper and Paccagnella M analyzed the data; Merlano MC revised the manuscript for important intellectual content.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Vincenzo Ricci, MD, Doctor, Medical Oncology and Laboratory of Translational Oncology, Oncology Department, S. Croce and Carle Teaching Hospital, Via A. Carle 5, Cuneo 12100, Italy. vincenzoricci22@libero.it
Received: November 14, 2019
Peer-review started: November 14, 2019
First decision: November 18, 2019
Revised: February 7, 2020
Accepted: February 17, 2020
Article in press: February 17, 2020
Published online: March 15, 2020
Processing time: 119 Days and 0.8 Hours
Core Tip

Core tip: We analyzed levels of specific cytokines in plasma of metastatic colorectal cancer patients before treatment with regorafenib. Our aim was to identify biomarkers useful to select metastatic colorectal cancer responder patients and an immune profile potentially correlated with the outcome.