Observational Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Feb 15, 2020; 12(2): 219-227
Published online Feb 15, 2020. doi: 10.4251/wjgo.v12.i2.219
Clinical value evaluation of serum markers for early diagnosis of colorectal cancer
Wen-Yue Song, Xin Zhang, Qi Zhang, Peng-Jun Zhang, Rong Zhang
Wen-Yue Song, Qi Zhang, Rong Zhang, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning Province, China
Wen-Yue Song, Xin Zhang, Qi Zhang, Peng-Jun Zhang, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Interventional Therapy Department, Peking University Cancer Hospital and Institute, Beijing 100142, China
Author contributions: Song WY, Zhang PJ, and Zhang R designed the study; Song WY, Zhang X, and Zhang Q performed the research; Song WY, Zhang PJ , and Zhang R analyzed the date; Song WY wrote the paper; Zhang PJ and Zhang R revised the manuscript for final submission; Song WY and Zhang X contributed equally to this study; Zhang PJ and Zhang R are the co-corresponding authors.
Supported by National Key R and D Program of China, No. 2016YFC0106604; National Natural Science Foundation of China, No. 81502591.
Institutional review board statement: The study was reviewed and approved by the Peking University Cancer Hospital and Institute review board.
Informed consent statement: All study participants or their legal guardian provided written informed consent prior to study enrollment.
Conflict-of-interest statement: We declare that we have no financial or personal relationships with other individuals or organizations that can inappropriately influence our work and that there is no professional or other personal interest of any nature in any product, service and/or company that could be construed as influencing the position presented in or the review of the manuscript.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement – checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Rong Zhang, PhD, Professor, Teacher, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, No. 103 Wenhua Road, Shenyang 110016, Liaoning Province, China. zhangrong7110@163.com
Received: December 18, 2019
Peer-review started: December 18, 2019
First decision: January 13, 2020
Revised: January 17, 2020
Accepted: February 8, 2020
Article in press: February 8, 2020
Published online: February 15, 2020
Processing time: 59 Days and 2.2 Hours
Core Tip

Core tip: We aimed to combine the serum index together by several multiparameter method, such as, the binary logistic regression, discriminant analysis, classification tree and artificial neural network analysis. Finally, a multiparameter diagnostic model based on artificial neural network which showed better diagnostic value was built for the early detection of colorectal cancer.