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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Sep 15, 2019; 11(9): 705-716
Published online Sep 15, 2019. doi: 10.4251/wjgo.v11.i9.705
Published online Sep 15, 2019. doi: 10.4251/wjgo.v11.i9.705
MicroRNA-331 inhibits development of gastric cancer through targeting musashi1
Lei-Ying Yang, Li Wang, Qin-Lai Liu, Department of Pathology, Shandong First Medical University, Taian 271016, Shandong Province, China
Guang-Le Song, Morphological Laboratory, Shandong First Medical University, Taian 271016, Shandong Province, China
Xiao-Qian Zhai, Department of Pathology, Second Affiliated Hospital of Shandong First Medical University, Taian 271016, Shandong Province, China
Ming-Shun Zhou, Department of Emergency, Second Affiliated Hospital of Shandong First Medical University, Taian 271016, Shandong Province, China
Author contributions: Zhou MS designed research; Yang LY, Song GL, Zhai XQ, Wang L and Liu QL performed research; Yang LY analyzed data; Yang LY and Zhou MS wrote the paper.
Institutional animal care and use committee statement: The study was approved by the Institutional Animal Care and Use Committee of Affiliated Hospital Taishan Medical University.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The ARRIVE Guidelines have been adopted.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ming-Shun Zhou, PhD, Professor, Department of Emergency, Second Affiliated Hospital of Shandong First Medical University, Taian 271016, Shandong Province, China. zhoumingshun790@163.com
Telephone: +86-538-6998075Fax: +86-538-6998075
Received: March 17, 2019
Peer-review started: March 18, 2019
First decision: March 28, 2019
Revised: April 10, 2019
Accepted: July 16, 2019
Article in press: July 17, 2019
Published online: September 15, 2019
Processing time: 181 Days and 1.5 Hours
Peer-review started: March 18, 2019
First decision: March 28, 2019
Revised: April 10, 2019
Accepted: July 16, 2019
Article in press: July 17, 2019
Published online: September 15, 2019
Processing time: 181 Days and 1.5 Hours
Core Tip
Core tip: Gastric cancer (GC) has become one of the main threats to human life and health. MicroRNAs (miRNAs) have been reported to act as promoters and inhibitors in GC. In this study, the effect of miR-331 on cell metastasis and tumor growth was illuminated in GC. The results showed that miR-331 was downregulated in GC, which predicted poor prognosis in GC patients. Moreover, overexpression of miR-331 inhibited cell metastasis and tumor growth in GC cells. Further, musashi1 (MSI1) is a direct target gene of miR-331. MiR-331 inhibited GC progression through the suppression of MSI1.