Review
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Sep 15, 2019; 11(9): 652-664
Published online Sep 15, 2019. doi: 10.4251/wjgo.v11.i9.652
Advancements and challenges in treating advanced gastric cancer in the West
Jennifer L Leiting, Travis E Grotz
Jennifer L Leiting, Travis E Grotz, Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic, Rochester, MN 55905, United States
Author contributions: Leiting JL and Grotz TE conceived and drafted the manuscript; both authors approved the final version of the article.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Travis E Grotz, MD, Assistant Professor, Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN 55905, United States. grotz.travis@mayo.edu
Telephone: +1-507-2841529Fax: +1-507-2845196
Received: February 6, 2019
Peer-review started: February 12, 2019
First decision: June 4, 2019
Revised: July 2, 2019
Accepted: July 29, 2019
Article in press: July 29, 2019
Published online: September 15, 2019
Processing time: 218 Days and 6.8 Hours
Core Tip

Core tip: The treatment of advanced gastric cancer in the West continues to evolve and advance. Surgery-related outcomes continue to improve and have included the addition of minimally invasive surgery techniques. The use of chemotherapy to improve long-term survival outcomes has been demonstrated in randomized-controlled trials, though the best regimen to use continues to be investigated. Chemoradiation has also been shown to improve outcomes, though the timing, sequence, and patient-population for optimal benefit has yet to be determined. Targeted-therapies and intraperitoneal chemotherapy may also play a role in the treatment of patients with advanced gastric cancer.