Basic Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jun 15, 2019; 11(6): 470-488
Published online Jun 15, 2019. doi: 10.4251/wjgo.v11.i6.470
Plasma and wound fluid levels of eight proangiogenic proteins are elevated after colorectal resection
HMC Shantha Kumara, Xiao-Hong Yan, Erica Pettke, Vesna Cekic, Nipa Dilip Gandhi, Geoffrey A Bellini, Richard L Whelan
HMC Shantha Kumara, Xiao-Hong Yan, Erica Pettke, Vesna Cekic, Nipa Dilip Gandhi, Geoffrey A Bellini, Richard L Whelan, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai West Hospital, New York, NY 10019, United States
Richard L Whelan, Department of Surgery, Mount Sinai Icahn School of Medicine, New York, NY 10029, United States
Author contributions: Shantha Kumara HMC contributed to the conception, design, sample processing, statistical analysis and interpretation of data, and revision of the articles; Yan XH contributed to collection of human material clinical data, revision of the article, Pettke E, Gandhi ND, Bellini GA and Cekic V contributed to human sample collection, processing, analysis and interpretation of data; Whelan RL contributed to the conception, design, interpretation of data, critical revision of the article; all authors drafted the article and made critical revisions and approved the submitted final version of the article to be published.
Supported by a generous donation from the Thompson Family Foundation to the Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai West Hospital, New York.
Institutional review board statement: This study was reviewed and approved by Mount Sinai Hospital, New York IRB.
Conflict-of-interest statement: All authors have no conflicts of interest or financial ties to disclose.
Data sharing statement: No additional data available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Richard L Whelan, MD, Professor, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai West Hospital, Suite 7B, 425 West, 59th Street, New York, NY 10019, United States. richard.whelan@mountsinai.org
Telephone: +1-212-5238172 Fax: +1-212-5238857
Received: October 19, 2018
Peer-review started: October 19, 2018
First decision: December 10, 2018
Revised: March 7, 2019
Accepted: March 16, 2019
Article in press: March 16, 2019
Published online: June 15, 2019
Core Tip

Core tip: Simultaneous postoperative (postop) measurement of plasma and wound fluid levels of 8 proangiogenic proteins for 3 wk after colorectal resection was carried out in 66 patients. Wound fluid protein levels were 3-106 times greater than postop plasma levels which, in turn, were significantly greater than preoperative plasma levels. Colorectal resection is associated with persistent systemic blood protein changes that might stimulate tumor angiogenesis and, thus, tumor growth in residual tumor deposits during the first month after surgery. It is hypothesized that the healing wounds are a major source of the added protein in the blood stream.