Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. May 15, 2019; 11(5): 367-376
Published online May 15, 2019. doi: 10.4251/wjgo.v11.i5.367
Stereotactic body radiation therapy in patients with hepatocellular carcinoma: A mini-review
Sabine Gerum, Alexandra D Jensen, Falk Roeder
Sabine Gerum, Department of Radiation Oncology, University Hospital LMU Munich, Munich, 81377, Germany
Alexandra D Jensen, Department of Radiation Oncology, University Hospital Gießen and Marburg, Marburg, 35043, Germany
Falk Roeder, CCU Molecular Radiation Oncology, German Cancer Research Center, Heidelberg, 74626, Germany
Falk Roeder, Department of Radiotherapy and Radiation Oncology, Paracelsus Medical University, Salzburg, 5020, Austria
Author contributions: Gerum S participated in drafting the manuscript, generated the figures and assisted in literature research; Jensen AD drafted the parts dealing with particle therapy and critically reviewed the manuscript, Roeder F drafted the manuscript, generated the tables and performed the literature research.
Conflict-of-interest statement: All authors declare no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Falk Roeder, MD, Associate Professor, Department of Radiotherapy and Radiation Oncology, Paracelsus Medical University, Landeskrankenhaus Salzburg, Müllner Hauptstrasse 48, Salzburg, 5020, Austria.
Telephone: +43-5-725527101 Fax: +43-5-725527299
Received: January 16, 2019
Peer-review started: January 17, 2019
First decision: January 26, 2019
Revised: March 14, 2019
Accepted: March 27, 2019
Article in press: March 28, 2019
Published online: May 15, 2019
Core Tip

Core tip: Stereotactic body radiation therapy (SBRT) is an emerging treatment for hepatocellular carcinoma. It may be used as a sole treatment or in combination with other local therapies as well as a bridging strategy for patient awaiting transplants and results in excellent local control rates with low toxicity. This mini-review describes current concepts of SBRT and summarizes the available evidence evaluating SBRT alone, SBRT in combination with other treatments and SBRT compared to other local treatment approaches.