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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Apr 15, 2019; 11(4): 322-334
Published online Apr 15, 2019. doi: 10.4251/wjgo.v11.i4.322
Published online Apr 15, 2019. doi: 10.4251/wjgo.v11.i4.322
Validated model for prediction of recurrent hepatocellular carcinoma after liver transplantation in Asian population
Ka Wing Ma, Wong Hoi She, Wing Chiu Dai, Department of Surgery, the University of Hong Kong, Hong Kong, China
Albert Chi Yan Chan, Tan To Cheung, Chung Mau Lo, Kenneth Siu Ho Chok, Department of Surgery and State Key Laboratory for Liver Research, the University of Hong Kong, 102 Pokfulam Road, Hong Kong, China
James Yan Yue Fung, Department of Medicine and State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong, China
Author contributions: Ma KW was responsible for study design, data collection and analysis, manuscript writing, and proofreading; She WH, Chan ACY, Cheung TT, Fung JYY, Dai WC, and Lo CM were responsible for data collection and proofreading; Chok KSH was responsible for supervising the study, data collection, and proofreading.
Institutional review board statement: Institutional review board approval was not required for retrospective observational study.
Informed consent statement: Informed consent to the use of patient data for research purpose was obtained from all patients before transplantation.
Conflict-of-interest statement: None of the authors has any conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Kenneth Siu Ho Chok, FRCS (Ed), Associate Professor, Department of Surgery, the University of Hong Kong, 102 Pok Fu Lam Road, Hong Kong, China. chok6275@hku.hk
Telephone: +852-22553025
Received: November 19, 2018
Peer-review started: November 19, 2018
First decision: December 7, 2018
Revised: January 3, 2019
Accepted: January 8, 2019
Article in press: January 9, 2019
Published online: April 15, 2019
Processing time: 147 Days and 5.8 Hours
Peer-review started: November 19, 2018
First decision: December 7, 2018
Revised: January 3, 2019
Accepted: January 8, 2019
Article in press: January 9, 2019
Published online: April 15, 2019
Processing time: 147 Days and 5.8 Hours
Core Tip
Core tip: Recurrent hepatocellular carcinoma is the leading cause of death after liver transplantation. A validated predictive system for the chance of post-transplant recurrence of hepatocellular carcinoma is indispensable for stratifying patients into different risk groups. This study found that salvage liver transplantation, pre-transplant alpha-fetoprotein level, and the sum of pathological tumor size and number were the three independent factors associated with recurrence. Based on this, a scoring model was derived, validated, and found to have good concordance and is therefore recommendable to be used as a guide for postoperative patient surveillance.