Basic Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Mar 15, 2019; 11(3): 181-194
Published online Mar 15, 2019. doi: 10.4251/wjgo.v11.i3.181
Glycerophospholipids pathways and chromosomal instability in gastric cancer: Global lipidomics analysis
Cheng-Yu Hung, Ta-Sen Yeh, Cheng-Kun Tsai, Ren-Chin Wu, Ying-Chieh Lai, Meng-Han Chiang, Kuan-Ying Lu, Chia-Ni Lin, Mei-Ling Cheng, Gigin Lin
Cheng-Yu Hung, Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan
Cheng-Yu Hung, Cheng-Kun Tsai, Ying-Chieh Lai, Meng-Han Chiang, Kuan-Ying Lu, Mei-Ling Cheng, Gigin Lin, Clinical Metabolomics Core Lab, Chang Gung Memorial Hospital at Linkou and Chang Gung University, Taoyuan 333, Taiwan
Cheng-Yu Hung, Cheng-Kun Tsai, Ying-Chieh Lai, Meng-Han Chiang, Kuan-Ying Lu, Gigin Lin, Department of Medical Imaging and Intervention, Imaging Core Lab, Institute for Radiological Research, Chang Gung Memorial Hospital at Linkou and Chang Gung University, Taoyuan 333, Taiwan
Ta-Sen Yeh, Department of Surgery, Chang Gung Memorial Hospital at Linkou and Chang Gung University, Taoyuan 333, Taiwan
Ren-Chin Wu, Department of Pathology, Chang Gung Memorial Hospital at Linkou and Chang Gung University, Taoyuan 333, Taiwan
Chia-Ni Lin, Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou and Chang Gung University, Taoyuan 333, Taiwan
Mei-Ling Cheng, Department of Biomedical Science, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
Author contributions: Lin G conceived and designed the experiments; Yeh TS, Chiang MH, Lu KY and Hung CY performed the experiments; Hung CY and Chiang MH analyzed the data; Wu RC, Lai YC, Lin CN and Cheng ML contributed reagents, materials, and analysis tools; Hung CY and Lin G wrote the paper.
Supported by the funding from the Ministry of Science and Technology Taiwan grant, No. MOST 106-2314-B-182A-019-MY3; and the Chang Gung Foundation, No. CMRPG3E1321-2.
Institutional review board statement: All procedures in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Gigin Lin, MD, PhD, Director, Department of Medical Imaging and Intervention, Imaging Core Lab, Institute for Radiological Research, Metabolomics Core Lab, Chang Gung Memorial Hospital at Linkou and Chang Gung University, Fuhsing 5, Taoyuan 333, Taiwan. giginlin@cgmh.org.tw
Telephone: +886-3-3281200-2575 Fax: +886-3-3971936
Received: November 15, 2018
Peer-review started: November 15, 2018
First decision: December 7, 2018
Revised: December 17, 2018
Accepted: December 23, 2018
Article in press: December 24, 2018
Published online: March 15, 2019
Processing time: 120 Days and 15.1 Hours
Core Tip

Core tip: We investigated the correlation between comprehensive lipidomic profiles of gastric cancer and the tumor’s chromosomal instability (CIN) status. In this disease landscape study, which involved no pre-specified hypotheses, we combined a gene molecule classification method with a lipidomic method to discover metabolic information for accurate tumor classification. CIN-status-based lipidomics profiling demonstrated translational potential for biomarker discovery and development of novel therapeutic strategies.