Copyright
©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Feb 15, 2019; 11(2): 139-152
Published online Feb 15, 2019. doi: 10.4251/wjgo.v11.i2.139
Published online Feb 15, 2019. doi: 10.4251/wjgo.v11.i2.139
C-reactive protein may be a prognostic factor for the whole gastroenteropancreatic neuroendocrine tumor group
Ömer Komaç, Department of Internal Medicine, Dokuz Eylul University Faculty of Medicine, Izmir 35000, Turkey
Göksel Bengi, Mesut Akarsu, Department of Gastroenterology, Dokuz Eylul University Faculty of Medicine, Izmir 35000, Turkey
Özgül Sağol, Department of Pathology, Dokuz Eylul University Faculty of Medicine, Izmir 35000, Turkey
Author contributions: Bengi G, Komaç Ö, Akarsu M and, Sağol Ö contributed equally to this work, designed the research, drafted the manuscript and provided the administrative and technical support.
Institutional review board statement: This study was approved by the Ethics Committee of Dokuz Eylul University in June 2017.
Informed consent statement: Informed consent was provided by all the participants.
Conflict-of-interest statement: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Göksel Bengi, MD, Assistant Professor, Department of Gastroenterology, Dokuz Eylul University Faculty of Medicine, Inciralti, Izmir 35000, Turkey. drgokselbengi@hotmail.com
Telephone: +90-532-4626972 Fax: +90-232-4123799
Received: April 20, 2018
Peer-review started: April 21, 2018
First decision: May 29, 2018
Revised: August 24, 2018
Accepted: October 23, 2018
Article in press: October 23, 2018
Published online: February 15, 2019
Peer-review started: April 21, 2018
First decision: May 29, 2018
Revised: August 24, 2018
Accepted: October 23, 2018
Article in press: October 23, 2018
Published online: February 15, 2019
Core Tip
Core tip: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) constitute a heterogeneous group of tumors with variable clinical presentations, different growth rates, and unpredictable prognoses. In our study, we aimed to identify the independent prognostic markers for the whole GEP-NET group. It was observed that the biochemical parameter, C-reactive protein (CRP), affected disease progression (particularly if it was > 20 mg/dL). However, larger scale prospective studies are required to determine whether CRP level may be a poor prognostic factor for the entire GEP-NET group.