Basic Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Nov 15, 2019; 11(11): 971-982
Published online Nov 15, 2019. doi: 10.4251/wjgo.v11.i11.971
Calponin 3 promotes invasion and drug resistance of colon cancer cells
Vidhya A Nair, Noura A Al-khayyal, Sivaramakrishnan Sivaperumal, Wael M Abdel-Rahman
Vidhya A Nair, Environment and Cancer Research Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates
Noura A Al-khayyal, College of Medicine and Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates
Sivaramakrishnan Sivaperumal, Department of Biotechnology, Bharathidasan University, Tiruchirappalli 620024, India
Wael M Abdel-Rahman, Department of Medical Laboratory Sciences, College of Health Sciences and Environment and Cancer Research Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates
Author contributions: Abdel-Rahman WM supported the study, designed the project, obtained funding, contributed to the laboratory work, provided study material, analyzed and interpreted the data, and wrote the manuscript; Nair VA developed the ideas, performed the experiments, and contributed to data analysis; Al-khayyal NA performed the experiments and contributed to data analysis; Sivaperumal S provided critical insights and contributed to the data analysis and write up; All authors revised and endorsed the final draft.
Institutional review board statement: Work involving human tissue was according to ethical standards of Helsinki declaration and under the approval of the Ethics and Research Committee at the University of Sharjah.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: All relevant data were presented in the manuscript. Further information is available from the corresponding author.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Wael M Abdel-Rahman, MD, PhD, Full Professor, Department of Medical Laboratory Sciences, College of Health Sciences and Environment and Cancer Research Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates. whassan@sharjah.ac.ae
Telephone: +971-6-5057556 Fax: +971-6-5057515
Received: March 6, 2019
Peer-review started: March 8, 2019
First decision: April 15, 2019
Revised: July 27, 2019
Accepted: September 12, 2019
Article in press: September 12, 2019
Published online: November 15, 2019
Processing time: 255 Days and 15.3 Hours
Core Tip

Core tip: We hypothesized that calponin 3 (CNN3) may play a role in carcinogenesis based upon its known biological functions. We showed that it is expressed in colon and breast cancer cells and is associated with the metastatic phenotype in colon cancer via upregulating mesenchymal markers. CNN3 also improves the sensitivity to chemotherapy in these tumors. We also showed that it is linked to other carcinogenic pathways such as extracellular signal-regulated kinase 1/2, β-Catenin, mutant p53, c-Jun, and heat shock protein 60 in colorectal cancer. Thus, CNN3 is a promising biomarker in colon cancer.