Prospective Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Apr 15, 2018; 10(4): 96-102
Published online Apr 15, 2018. doi: 10.4251/wjgo.v10.i4.96
Prospective real-time evaluation of diagnostic performance using endocytoscopy in differentiating neoplasia from non-neoplasia for colorectal diminutive polyps (≤ 5 mm)
Takahiro Utsumi, Yasushi Sano, Mineo Iwatate, Hironori Sunakawa, Akira Teramoto, Daizen Hirata, Santa Hattori, Wataru Sano, Noriaki Hasuike, Kazuhito Ichikawa, Takahiro Fujimori
Takahiro Utsumi, Yasushi Sano, Mineo Iwatate, Hironori Sunakawa, Akira Teramoto, Daizen Hirata, Santa Hattori, Wataru Sano, Noriaki Hasuike, Gastrointestinal Center and Institute of Minimally Invasive Endoscopic Care (iMEC), Sano Hospital, Hyogo 655-0031, Japan
Kazuhito Ichikawa, Takahiro Fujimori, Department of Pathology, Shinko Hospital, Hyogo 651-0072, Japan
Author contributions: Utsumi T, Sano Y, Iwatate M, Sunakawa H, Teramoto A, Hirata D, Sano W, Hasuike N, Ichikawa K and Fujimori T designed the study; Utsumi T collected the data; Utsumi T, Sano Y and Iwatate M drafted the study, analyzed the data and wrote the manuscript.
Institutional review board statement: This study was approved by the Institutional Review Board at Sano Hospital.
Informed consent statement: Written informed consent for the procedures was obtained from all patients.
Conflict-of-interest statement: None.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yasushi Sano, MD, PhD, Doctor, Professor, Gastrointestinal Center and Institute of Minimally Invasive Endoscopic Care (iMEC), Sano Hospital, 2-5-1 Shimizugaoka, Tarumi-ku, Hyogo 655-0031, Japan. ys_endoscopy@hotmail.com
Telephone: +81-78-7851000 Fax: +81-78-7850077
Received: December 17, 2017
Peer-review started: December 17, 2017
First decision: January 6, 2018
Revised: January 10, 2018
Accepted: March 6, 2018
Article in press: March 6, 2018
Published online: April 15, 2018
Processing time: 120 Days and 6 Hours
Core Tip

Core tip: Single-Charge Coupled Device integrated type endocytoscopy (OLYMPUS, Japan) is going to be newly launched in 2018. Endocytoscopy with approximately 500-fold magnification capability allows us to observe both structural and cellular atypia in vivo, and is expected to be used as an optical biopsy. In our prospective study, we aimed to clarify the diagnostic performance of endocytoscopy in differentiating neoplasia from non-neoplasia for colorectal diminutive polyps (≤ 5 mm). The diagnostic performance of endocytoscopy met the threshold of the Preservation and Incorporation of Valuable endoscopic Innovations statement for “resect-and-discard” and “diagnose-and-leave” strategies.