Published online Apr 15, 2024. doi: 10.4251/wjgo.v16.i4.1192
Peer-review started: October 17, 2023
First decision: January 15, 2024
Revised: January 28, 2024
Accepted: February 28, 2024
Article in press: February 28, 2024
Published online: April 15, 2024
Patients with hepatocellular carcinoma (HCC) have a high rate of early recurrence after radical treatment, and the survival rate is not satisfactory.
To understand the risk factors for early recurrence of HCC. For patients who are predicted to have high risk of early recurrence, subsequent treatment plans should be considered and this may result in longer survival compared with surgery alone.
To explore the value of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) enhanced magnetic resonance imaging (MRI) combined with clinical features in predicting early recurrence of HCC after resection, and find out the predictive factors related with early recurrence of HCC.
This retrospective cohort study enrolled 161 patients pathologically confirmed HCC and classified into early recurrence and non-early recurrence group based on the follow-up results. The clinical, laboratory, pathological results and Gd-EOB-DTPA enhanced MRI imaging features were analyzed.
Results showed that patient age, microvascular invasion, China liver cancer stage, tumor boundary and large vessel invasion were independent predictive factors for early recurrence of HCC. This result was further validated by external data and showed good predictive performance.
We found Gd-EOB-DTPA enhanced MRI combined with clinical features would help predicting the early recurrence of HCC after operation.
The outcoming and prognosis of patients with high risk of early recurrence after personalized treatment plans according to our results would be observed.