Chen JP, Yang RH, Zhang TH, Liao LA, Guan YT, Dai HY. Pre-operative enhanced magnetic resonance imaging combined with clinical features predict early recurrence of hepatocellular carcinoma after radical resection. World J Gastrointest Oncol 2024; 16(4): 1192-1203 [PMID: 38660657 DOI: 10.4251/wjgo.v16.i4.1192]
Corresponding Author of This Article
Hai-Yang Dai, MD, Chief Doctor, Deputy Director, Department of Medical Imaging, Huizhou Municipal Central Hospital, No. 41 North Eling Road, Huizhou 516001, Guangdong Province, China. d.ocean@163.com
Research Domain of This Article
Radiology, Nuclear Medicine & Medical Imaging
Article-Type of This Article
Retrospective Cohort Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Apr 15, 2024; 16(4): 1192-1203 Published online Apr 15, 2024. doi: 10.4251/wjgo.v16.i4.1192
Pre-operative enhanced magnetic resonance imaging combined with clinical features predict early recurrence of hepatocellular carcinoma after radical resection
Jian-Ping Chen, Department of Intervention, Meizhou People’s Hospital, Meizhou 514031, Guangdong Province, China
Ri-Hui Yang, Tian-Hui Zhang, Li-An Liao, Yu-Ting Guan, Department of Medical Imaging, Meizhou People’s Hospital, Meizhou 514031, Guangdong Province, China
Hai-Yang Dai, Department of Medical Imaging, Huizhou Municipal Central Hospital, Huizhou 516001, Guangdong Province, China
Co-first authors: Jian-Ping Chen and Ri-Hui Yang.
Author contributions: Chen JP and Yang RH contributed equally to this work; Chen JP wrote the first draft, and contributed to the writing of subsequent versions; Data was acquired and prepared for analysis by Yang RH and Liao LA; Statistical analyses and preparation of tables and figures was performed by Guan YT and Zhang TH; Dai HY was responsible for project administration and supervision; and all authors participated in the study design, interpretation of the data, and critically reviewing the paper.
Institutional review board statement: This study was reviewed and approved by the Meizhou People’s Hospital Institutional Review Board (Approval No. 2022-C-36).
Informed consent statement: The informed consent was waived from the patients and the presented data are anonymized.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at d.oocean@163.com.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai-Yang Dai, MD, Chief Doctor, Deputy Director, Department of Medical Imaging, Huizhou Municipal Central Hospital, No. 41 North Eling Road, Huizhou 516001, Guangdong Province, China. d.ocean@163.com
Received: October 17, 2023 Peer-review started: October 17, 2023 First decision: January 15, 2024 Revised: January 28, 2024 Accepted: February 28, 2024 Article in press: February 28, 2024 Published online: April 15, 2024 Processing time: 176 Days and 13.8 Hours
ARTICLE HIGHLIGHTS
Research background
Patients with hepatocellular carcinoma (HCC) have a high rate of early recurrence after radical treatment, and the survival rate is not satisfactory.
Research motivation
To understand the risk factors for early recurrence of HCC. For patients who are predicted to have high risk of early recurrence, subsequent treatment plans should be considered and this may result in longer survival compared with surgery alone.
Research objectives
To explore the value of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) enhanced magnetic resonance imaging (MRI) combined with clinical features in predicting early recurrence of HCC after resection, and find out the predictive factors related with early recurrence of HCC.
Research methods
This retrospective cohort study enrolled 161 patients pathologically confirmed HCC and classified into early recurrence and non-early recurrence group based on the follow-up results. The clinical, laboratory, pathological results and Gd-EOB-DTPA enhanced MRI imaging features were analyzed.
Research results
Results showed that patient age, microvascular invasion, China liver cancer stage, tumor boundary and large vessel invasion were independent predictive factors for early recurrence of HCC. This result was further validated by external data and showed good predictive performance.
Research conclusions
We found Gd-EOB-DTPA enhanced MRI combined with clinical features would help predicting the early recurrence of HCC after operation.
Research perspectives
The outcoming and prognosis of patients with high risk of early recurrence after personalized treatment plans according to our results would be observed.
