Published online Mar 15, 2024. doi: 10.4251/wjgo.v16.i3.844
Peer-review started: October 20, 2023
First decision: December 5, 2023
Revised: December 15, 2023
Accepted: January 17, 2024
Article in press: January 17, 2024
Published online: March 15, 2024
Processing time: 144 Days and 3.6 Hours
Hepatocellular carcinoma (HCC) is one of the most common tumors today. It is known that patients with HCC will have a higher risk of cardiovascular disease (CVD) death compared to non-HCC patients.
CVD is recognized as one of the most common complications of cancer treatment. As medical technology continues to mature, studies have found that the 5-year survival rate for HCC patients can be increased to 70% with early diagnosis and some potential treatments. Just because there are some unique treatment modalities (e.g. Transcatheter arterial che
The aim of this study was to identify the independent risk factors for CVD death in HCC patients, and to further provide a reference tool for the relevant clinical management decisions of HCC patients by constructing a prediction model for CVD death in HCC patients.
In this study, data related to adult HCC patients with diagnosis years 2010-2015 in the Surveillance, Epidemiology, and End Results database were collected. In order to better eliminate the influence of competing events on the study, we utilized the Fine-Gray model to carry out the analysis and constructed a predictive model.
The study included 21545 patients with HCC, of whom 619 died of CVD. Age, marital status, alpha fetoprotein, tumor size, surgery, and chemotherapy were independent risk factors for CVD death in HCC patients. The discrimination as well as the calibration of the nomograph was better. Decision curve analysis demonstrated that the prediction model has a high net benefit.
This study focuses on the cardiovascular risk of HCC patients for the first time. Meanwhile, the independent risk factors for CVD deaths in HCC patients were explored for the first time based on the Fine-Gray model, and a prediction model was constructed, which will serve as a reminder for future clinical work.
Focusing on the burden of CVD in HCC patients and further exploring the impact of different drugs and routes of administration on CVD death in HCC patients.