Zheng L, Li B, Lei L, Wang LJ, Zeng ZP, Yang JD. Effect of screening colonoscopy frequency on colorectal cancer mortality in patients with a family history of colorectal cancer. World J Gastrointest Oncol 2024; 16(2): 354-363 [PMID: 38425395 DOI: 10.4251/wjgo.v16.i2.354]
Corresponding Author of This Article
Jian-Dong Yang, Doctor, Occupational Physician, Department of General Surgery, The First Hospital of Nanchang, No. 128 Xiangshan North Road, Nanchang 330008, Jiangxi Province, China. yjd-009@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Feb 15, 2024; 16(2): 354-363 Published online Feb 15, 2024. doi: 10.4251/wjgo.v16.i2.354
Effect of screening colonoscopy frequency on colorectal cancer mortality in patients with a family history of colorectal cancer
Li Zheng, Bin Li, Ling Lei, Li-Jia Wang, Zhi-Ping Zeng, Jian-Dong Yang
Li Zheng, Bin Li, Ling Lei, Li-Jia Wang, Zhi-Ping Zeng, Department of Gastroenterology, The First Hospital of Nanchang, Nanchang 330008, Jiangxi Province, China
Jian-Dong Yang, Department of General Surgery, The First Hospital of Nanchang, Nanchang 330008, Jiangxi Province, China
Author contributions: Zheng L and Yang JD contributed equally to this work; Zheng L, Li B, Lei L, Wang LJ, Zeng ZP, and Yang JD designed the study and were involved in the data acquisition and writing of this article; Zheng L and Yang JD contributed to the analysis of the manuscript; and all authors have read and approved the final manuscript.
Supported byScience and Technology Plan of Jiangxi Provincial Health Commission, No. 202311202 and No. SKJP220219076; and the Science and Technology Support Plan Project of Nanchang, Jiangxi Province, No. 2020-133-5.
Institutional review board statement: The study was reviewed and approved by the First Hospital of Nanchang Institutional Review Board.
Informed consent statement: All patients provided written informed consent for participation in the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Dong Yang, Doctor, Occupational Physician, Department of General Surgery, The First Hospital of Nanchang, No. 128 Xiangshan North Road, Nanchang 330008, Jiangxi Province, China. yjd-009@163.com
Received: October 23, 2023 Peer-review started: October 23, 2023 First decision: November 8, 2023 Revised: November 13, 2023 Accepted: December 11, 2023 Article in press: December 11, 2023 Published online: February 15, 2024 Processing time: 102 Days and 6.8 Hours
ARTICLE HIGHLIGHTS
Research background
Colorectal cancer is one of the common malignant tumors in China, and its incidence in the elderly population has steadily increased. Inflammatory bowel disease is a group of chronic non-specific intestinal inflammatory diseases, including ulcerative colitis and Crohn 's disease.
Research motivation
To evaluate the effect of colonoscopy frequency on the mortality of colorectal cancer.
Research objectives
We included the clinicopathological and follow-up data of patients with colorectal cancer who underwent laparoscopic colectomy or open colectomy at our gastrointestinal department.
Research methods
Surgical indicators, oncological indicators, and survival rates were compared between the groups. The results of 104 patients who met the inclusion criteria were extracted from the database (laparoscopic colectomy group = 63, open colectomy group = 41), and there were no statistically significant differences in the baseline data or follow-up time between the two groups.
Research results
Intraoperative blood loss, the time to firs ambulation, and time to first liquid meal in the laparoscopic colectomy group were significantly lower than those in the open colectomy group. There was no significant difference in total mortality, tumor-related mortality, or recurrence rate between the two groups. Survival analysis showed that there was no significant difference in cumulative overall survival rate, tumor-related survival rate, or cumulative recurrence-free survival rate between the two groups.
Research conclusions
In elderly patients with colorectal cancer, laparoscopic colectomy has better short-term outcomes than open colectomy.
Research perspectives
Laparoscopic colectomy has superior long-term survival outcomes compared with open colectomy.
