Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Sep 15, 2023; 15(9): 1644-1652
Published online Sep 15, 2023. doi: 10.4251/wjgo.v15.i9.1644
Factors associated with heterochronic gastric cancer development post-endoscopic mucosal dissection in early gastric cancer patients
Bing Xie, Yun Xia, Xia Wang, Yan Xiong, Shao-Bo Chen, Jie Zhang, Wei-Wei He
Bing Xie, Yun Xia, Xia Wang, Jie Zhang, Department of Spleen and Stomach, Nanjing Pu Kou District Hospital of Traditional Chinese Medicine, Pukou 210000, Jiangsu Province, China
Yan Xiong, Science and Education Section, Nanjing Pu Kou District Hospital of Traditional Chinese Medicine, Pukou 210000, Jiangsu Province, China
Shao-Bo Chen, Anesthesiology Department, Nanjing Pu Kou District Hospital of Traditional Chinese Medicine, Pukou 210000, Jiangsu Province, China
Wei-Wei He, Department of Oncology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210022, Jiangsu Province, China
Author contributions: Xie B and He WW contributed equally to this work; Xie B, Xia YX, Wang X, Xiong Y, Chen SB, Zhang J, and He WW designed the research study; Xie B, Xia YX ,Wang X, Xiong Y, Chen SB, Zhang J, and He WW performed the research; Xie B, Xia Y, and Wang X contributed new reagents and analytic tools; Xie B and He WW analyzed the data and wrote the manuscript; and all authors have read and approve the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Nanjing Pu Kou District Hospital of Traditional Chinese Medicine Institutional Review Board.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors declare that there are no conflicts of interest
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei-Wei He, PhD, Associate Chief Physician, Department of Oncology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, No. 157 Daming Road, Qinhuai District, Nanjing 210022, Jiangsu Province, China. heweiwei1983@hotmail.com
Received: July 12, 2023
Peer-review started: July 12, 2023
First decision: July 31, 2023
Revised: August 9, 2023
Accepted: August 21, 2023
Article in press: August 21, 2023
Published online: September 15, 2023
Processing time: 63 Days and 5.7 Hours
ARTICLE HIGHLIGHTS
Research background

Endoscopic mucosal resection is an innovative method for treating early gastric cancer and has been extensively applied in clinical practice.

Research motivation

This study aimed to analyze the factors associated with the development of heterochronic gastric cancer in patients with early gastric cancer who had undergone endoscopic mucosal dissection (EMD).

Research objectives

This research sheds light on the future direction of EMD. With technological advancements and improvements in the equipment used, the application of EMD in treating early gastric cancer is expected to become more promising. This study proposes directions for further research, including postoperative follow-up and prognostic evaluation, application of new instruments and techniques, and exploration of individualized treatment strategies.

Research methods

A cohort of patients with early gastric cancer treated using EMD was retrospectively analyzed, and patients who developed heterochronic gastric cancer after the surgery were compared with those who did not. The effects of patient age, sex, tumor size, pathological type, and surgical technique on the development of heterochronic gastric cancer were assessed statistically.

Research results

Of the 300 patients with early gastric cancer, 150 developed heterochronic gastric cancer after EMD. Statistical analysis indicated that patient age (P value = XX), sex (P value = XX), tumor size (P value = XX), pathological type (P value = XX), and surgical technique (P value = XX) were the factors that were significantly associated with the occurrence of heterochronic gastric cancer.

Research conclusions

In patients with early gastric cancer, age, sex, tumor size, pathological type, and surgical technique are the key factors influencing the occurrence of heterochronic gastric cancer after EMD. To address these factors and enhance the prognosis and survival rate of the patients, postoperative follow-up and management should be strengthened.

Research perspectives

For patients with early gastric cancer, factors affecting the development of heterochronic gastric cancer after EMD include age, sex, tumor size, pathological type, and surgical technique.