Published online Sep 15, 2023. doi: 10.4251/wjgo.v15.i9.1605
Peer-review started: June 14, 2023
First decision: July 7, 2023
Revised: July 15, 2023
Accepted: August 2, 2023
Article in press: August 2, 2023
Published online: September 15, 2023
The current prognostic significance of perigastric tumor deposits (TDs) in gastric cancer (GC) remains unclear.
The prognostic value of TDs in GC has not been extensively studied or confirmed. To date, no studies have investigated the prognostic significance of TDs in GC in detail. This study aimed to assess the prognostic value of perigastric TDs and put forward a new and appropriate TNM staging framework involving TDs for primary GC.
This study aimed to assess the prognostic value of perigastric TDs and put forward a new and appropriate TNM staging framework involving TDs for primary GC.
We retrospectively analyzed the pathological data of 6672 patients with GC who underwent gastrectomy or surgery for GC with other diseases from January 1, 2012 to December 31, 2017 at the Chinese PLA General Hospital. The patients were divided into TD-positive and TD-negative groups by using the method of propensity score matching. The differences between TD-positive and TD-negative patients were analyzed using binary logistic regression modeling. The Kaplan-Meier method was used to plot survival curves. Multivariate Cox regression modeling and the log-rank test were used to analyze the data.
With the new GC staging scheme including TDs, the survival curves of patients in the lower grade TNM stage with TDs were closer to those of patients in the higher grade TNM stage without TDs.
TDs are a poor prognostic factor in patients with primary GC, and a new TNM staging system combining TDs would be suitable for such patients.
From a clinical point of view, we found deficiencies in the current TNM staging system for GC and conducted this study.