Wang X, Wang JY, Chen M, Ren J, Zhang X. Clinical association between coagulation indicators and bone metastasis in patients with gastric cancer. World J Gastrointest Oncol 2023; 15(7): 1253-1261 [PMID: 37546561 DOI: 10.4251/wjgo.v15.i7.1253]
Corresponding Author of This Article
Xin Zhang, MD, Doctor, Department of Surgical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 West Yanta Road, Xi'an 710061, Shaanxi Province, China. zhangxinzh@stu.xjtu.edu.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Jul 15, 2023; 15(7): 1253-1261 Published online Jul 15, 2023. doi: 10.4251/wjgo.v15.i7.1253
Clinical association between coagulation indicators and bone metastasis in patients with gastric cancer
Xuan Wang, Jing-Ya Wang, Min Chen, Juan Ren, Xin Zhang
Xuan Wang, Min Chen, Juan Ren, Department of Radiotherapy and Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China
Jing-Ya Wang, Department of Gastroenterology, Xi'an Children's Hospital, Shaanxi Research Institute for Pediatric Diseases, The Affiliated Children's Hospital of Xi'an Jiaotong University and National Regional Medical Center for Children (Northwest), Xi'an 710003, Shaanxi Province, China
Xin Zhang, Department of Surgical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China
Author contributions: Wang X, Ren J and Zhang X designed the research study; Wang X, Wang JY and Chen M performed the research; Wang X analyzed the data and wrote the manuscript; all authors read and approve the final manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of First Affiliated Hospital of Xi’an Jiaotong University (Approval No. 2015-046).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: The authors declare that no competing interests exist.
Data sharing statement: Dataset available from the corresponding author at zhangxinzh@stu.xjtu.edu.cn
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xin Zhang, MD, Doctor, Department of Surgical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 West Yanta Road, Xi'an 710061, Shaanxi Province, China. zhangxinzh@stu.xjtu.edu.cn
Received: February 6, 2023 Peer-review started: February 6, 2023 First decision: March 15, 2023 Revised: March 16, 2023 Accepted: May 6, 2023 Article in press: May 6, 2023 Published online: July 15, 2023 Processing time: 156 Days and 5.7 Hours
ARTICLE HIGHLIGHTS
Research background
Bones are one of the most common targets for cancer metastasis. However, bone metastasis (BM) is often underdiagnosed because sensitive diagnostic imaging methods are recommended only after the onset of clinical symptoms. Patients with gastric cancer (GC), especially in advanced stages, are often in a hypercoagulable state.
Research motivation
The purpose of this study was to explore the predictive value of blood indicators on the risk of BM due to GC and to improve the diagnostic efficacy of BM due to GC by screening effective risk factors.
Research objectives
The purpose of this study was to explore whether coagulation indicators can be used as independent risk factors for predicting BM due to GC, thus promoting the early diagnosis and treatment of BM.
Research methods
We conducted a retrospective study and enrolled 454 patients in this study. Receiver operating characteristic (ROC) curves were used to assess diagnostic performance. Univariate and multivariate logistic regression analyses were used to evaluate the relationship between biomarkers and BM.
Research results
ROC curve analysis indicated that coagulation markers have similar or better diagnostic efficacy than traditional GC markers. Based on multivariate logistic regression analysis, prothrombin time, activated partial thromboplastin time and fibrin degradation products were independently associated with BM due to GC. Moreover, age, carcinoembryonic antigen, erythrocyte level and globulin were found to be risk factors of BM. Combining these indicators could improve the effectiveness of diagnosing BM.
Research conclusions
Coagulation markers (prothrombin time, activated partial thromboplastin time and fibrin degradation products), carcinoembryonic antigen and globulin were independent risk factors for BM due to GC. Patients with these risk factors should be screened early to detect BM due to GC and prevent bone-related events.
Research perspectives
Future research will explore the relationship and molecular mechanism between coagulation and tumor metastasis and explore new targets to block the process of tumor metastasis.
